Syngene International Ltd, Biocon Park, Plot Nos 2 and 3, Bommasandra 4th Phase, Jigani Link Road, Bangalore 560 100, India.
Eur J Med Chem. 2010 Mar;45(3):1206-10. doi: 10.1016/j.ejmech.2009.11.046. Epub 2009 Dec 4.
In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans.
在本研究中，合成了一系列含有 2-氟-4-甲氧基部分的新型 1,3,4-噁二唑衍生物。这些新合成的化合物通过 NMR、质谱、红外光谱研究以及 C、H、N 分析进行了表征。所有新合成的化合物都进行了抗菌和抗真菌研究。抗菌研究表明，化合物 4a 和 4b 对大肠杆菌和铜绿假单胞菌具有显著的抗菌活性，化合物 4i 对白色念珠菌具有显著的抗真菌活性。
