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1,1-双-(1,2,4-三唑基和1,3,4-噻二唑基)乙烷及苯乙烷衍生物作为潜在抗菌剂

1,1-Bis-(1,2,4-triazolyl and 1,3,4-thiadiazolyl) ethane and phenylethane derivatives as potential antibacterial agents.

作者信息

Abdelal A M, Gineinah M M, Nasr M N

机构信息

Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.

出版信息

Boll Chim Farm. 1998 Oct;137(9):372-6.

PMID:9859598
Abstract

A series of compounds containing two identical heterocyclic moieties such as triazole and thiadiazole separated by ethane or phenylethane was synthesized. The structures of the newly prepared compounds were established on the basis of their elemental analyses and spectral data. The target compounds were subjected to antifungal and antibacterial screening. The results of this testing revealed that compounds 23, 26, 34 and 35 showed promising antibacterial activity, while, compound 33 showed remarkable antifungal activity.

摘要

合成了一系列含有两个相同杂环部分(如三唑和噻二唑)的化合物,这些杂环部分由乙烷或苯乙烷隔开。根据新制备化合物的元素分析和光谱数据确定了它们的结构。对目标化合物进行了抗真菌和抗菌筛选。该测试结果表明,化合物23、26、34和35表现出有前景的抗菌活性,而化合物33表现出显著的抗真菌活性。

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