Kwok L S
Corneal Physiology and Biophysics Laboratory, College of Optometry, University of Houston, TX 77204-6052.
Doc Ophthalmol. 1991;77(1):1-38. doi: 10.1007/BF00154875.
The kinematics of wound closure in the healing rabbit corneal epithelium are modelled. The analysis is able to model the movement of the wound edge on the corneal surface. A unified formalism is described which embeds the surface velocity of the wound margin within the computational algorithm to enable calculation of the surface velocity of the wound margin from the time course of (1) planar wound area, or (2) wound diameter. The procedure can be implemented with the standard least-squares estimation procedure. A polynomial velocity function is discussed, but the model allows for any appropriate velocity function to be used to suit particular conditions of wound closure. Corneal curvature effects are incorporated to avoid the errors associated with a planar representation of wound closure on a curved corneal surface. The approach offers greater flexibility by avoiding the theoretical flaws of previous models which are often limited in scope and nonbiological in nature.
对愈合过程中的兔角膜上皮伤口闭合的运动学进行了建模。该分析能够模拟伤口边缘在角膜表面的移动。描述了一种统一的形式体系，该体系将伤口边缘的表面速度嵌入计算算法中，以便能够根据（1）平面伤口面积或（2）伤口直径的时间进程来计算伤口边缘的表面速度。该程序可以用标准的最小二乘法估计程序来实现。讨论了多项式速度函数，但该模型允许使用任何合适的速度函数以适应伤口闭合的特定条件。纳入了角膜曲率效应，以避免与在弯曲角膜表面上对伤口闭合进行平面表示相关的误差。该方法通过避免先前模型的理论缺陷提供了更大的灵活性，先前模型往往在范围上有限且本质上是非生物学的。
