Laboratories of The Rockefeller Institute for Medical Research, New York, and Hospital 21, Compiègne, France.
J Exp Med. 1916 Nov 1;24(5):451-60. doi: 10.1084/jem.24.5.451.
The cicatrization of sterile wounds may be studied in the same way as an ordinary physicochemical phenomenon. It is possible, therefore, to express the law of cicatrization by a mathematical equation as soon as an accurate measure of the wound can be obtained. By means of the equation, a curve is obtained which represents the theoretical evolution of the cicatrization of a wound. This curve, being an expression of what should happen on a normal wound, healing aseptically, on a normal man, is a daily point of comparison to what appears actually on the observed wound, and allows one to study accurately the fluctuations of cicatrization on a given individual, and the action of different dressings and antiseptic substances.
无菌伤口的愈合可以像普通物理化学现象一样进行研究。因此，只要能够准确测量伤口，就有可能通过数学方程来表达愈合规律。通过该方程，可以获得一条曲线，该曲线代表无菌愈合正常伤口的理论演变。这条曲线是无菌正常愈合的正常伤口应该发生的情况的一种表达，是观察到的实际伤口的每日比较点，并且可以准确研究特定个体的愈合波动以及不同敷料和防腐剂的作用。
