霍乱弧菌临床和环境分离株中RTX毒素的肌动蛋白交联活性
RTX toxin actin cross-linking activity in clinical and environmental isolates of Vibrio cholerae.
作者信息
Cordero Christina L, Sozhamannan Shanmuga, Satchell Karla J Fullner
机构信息
Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Tarry 3-713, Chicago, IL 60611, USA.
出版信息
J Clin Microbiol. 2007 Jul;45(7):2289-92. doi: 10.1128/JCM.00349-07. Epub 2007 May 23.
Abstract
Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within rtxA in the majority of clinical and environmental isolates tested, and the RTX toxin produced by these strains catalyzes the covalent cross-linking of cellular actin.
摘要
对来自不同O抗原组的霍乱弧菌菌株进行RTX毒素肌动蛋白交联活性评估。本研究表明，在大多数测试的临床和环境分离株中，rtxA内存在肌动蛋白交联结构域序列，并且这些菌株产生的RTX毒素催化细胞肌动蛋白的共价交联。
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本文引用的文献
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The Actin cross-linking domain of the Vibrio cholerae RTX toxin directly catalyzes the covalent cross-linking of actin.霍乱弧菌RTX毒素的肌动蛋白交联结构域直接催化肌动蛋白的共价交联。
J Biol Chem. 2006 Oct 27;281(43):32366-74. doi: 10.1074/jbc.M605275200. Epub 2006 Sep 5.
2
Identification of a domain within the multifunctional Vibrio cholerae RTX toxin that covalently cross-links actin.鉴定多功能霍乱弧菌RTX毒素中可与肌动蛋白共价交联的结构域。
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9798-803. doi: 10.1073/pnas.0401104101. Epub 2004 Jun 15.
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