强调FoxO蛋白在寿命和疾病中的作用。
Stressing the role of FoxO proteins in lifespan and disease.
作者信息
van der Horst Armando, Burgering Boudewijn M T
机构信息
Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.
出版信息
Nat Rev Mol Cell Biol. 2007 Jun;8(6):440-50. doi: 10.1038/nrm2190.
Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of FoxOs is tightly regulated by post-translational modifications, including phosphorylation, acetylation and ubiquitylation. Several of the enzymes that regulate the turnover of these post-translational modifications are shared between FoxO and p53. These regulatory enzymes affect FoxO and p53 function in an opposite manner. This shared yet opposing regulatory network between FoxOs and p53 may underlie a 'trade-off' between disease and lifespan.
叉头框转录因子（FoxO）家族成员在新陈代谢、细胞增殖、应激耐受以及可能的寿命方面发挥着重要作用。FoxO的活性受到翻译后修饰的严格调控，包括磷酸化、乙酰化和泛素化。调节这些翻译后修饰周转的几种酶在FoxO和p53之间是共享的。这些调节酶以相反的方式影响FoxO和p53的功能。FoxO和p53之间这种共享但相反的调节网络可能是疾病与寿命之间“权衡”的基础。
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