IgA肾病中IgA的糖基化不足：仅是一种诊断标志物吗？

Underglycosylation of IgA in IgA nephropathy: more than a diagnostic marker?

作者信息

Roos A, van Kooten C

机构信息

Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

Kidney Int. 2007 Jun;71(11):1089-91. doi: 10.1038/sj.ki.5002262.

DOI:10.1038/sj.ki.5002262

PMID:17522695

Abstract

Moldoveanu et al. present a diagnostic test for IgA nephropathy based on the presence of undergalactosylated IgA in serum. This underglycosylated IgA appears to be overrepresented in serum of IgA nephropathy patients and is most likely related to mesangial IgA deposition. Further studies on the nature, production, regulation, and cellular and molecular interactions of this undergalactosylated IgA may facilitate disease diagnosis and provide further insight into the pathogenesis of this important disease.

摘要

莫尔多万努等人提出了一种基于血清中低半乳糖基化IgA的存在来诊断IgA肾病的检测方法。这种低糖化IgA在IgA肾病患者的血清中似乎占比过高，并且很可能与系膜IgA沉积有关。对这种低半乳糖基化IgA的性质、产生、调节以及细胞和分子相互作用的进一步研究可能有助于疾病诊断，并为这种重要疾病的发病机制提供进一步的见解。