Daha Mohamed R, van Kooten Cees
Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.
J Nephrol. 2016 Feb;29(1):1-4. doi: 10.1007/s40620-015-0245-6. Epub 2015 Nov 13.
Immunoglobulin A nephropathy (IgAN) is characterized by the deposition of IgA in the mesangium of glomeruli. This mesangial IgA has been found to consist mainly of polymeric IgA1 which drives the activation of the mesangial cells and results in excessive production of several inflammatory mediators. The activation of mesangial cells is amplified by the ability of IgA to activate the complement system, originally thought to occur mainly via the alternative pathway of complement. However more recent studies indicate that lectin pathway involvement has a strong association with progression of renal disease. In this review we summarize the contribution of complement to the IgA- mediated inflammatory process.
免疫球蛋白A肾病（IgAN）的特征是IgA在肾小球系膜中沉积。已发现这种系膜IgA主要由聚合性IgA1组成，它驱动系膜细胞的激活，并导致多种炎症介质的过度产生。IgA激活补体系统的能力放大了系膜细胞的激活，最初认为补体激活主要通过补体替代途径发生。然而，最近的研究表明，凝集素途径的参与与肾脏疾病的进展密切相关。在这篇综述中，我们总结了补体在IgA介导的炎症过程中的作用。
