Potter John D
Fred Hutchinson Cancer Research Center, P.O. Box 19024, M4-B814, Seattle, Washington 98109-1024, USA.
Nat Rev Cancer. 2007 Jun;7(6):464-74. doi: 10.1038/nrc2146.
Morphogenetic fields organize tissue morphology in the embryo. By analogy, morphostatic fields maintain normal cell behaviour and normal tissue microarchitecture in the adult. The most prominent feature of cancer is the disruption of tissue microarchitecture. Cancer occurs much more frequently when morphostatic influences fail (metaplasia) or at the junction of two different morphostatic fields. This Review will describe what we know about morphostats and morphostasis, discuss the evidence for the role of disruption of morphostasis in malignancy, and address some testable hypotheses.
形态发生场在胚胎中组织组织形态。类推而言，形态稳定场在成体中维持正常的细胞行为和正常的组织微结构。癌症最显著的特征是组织微结构的破坏。当形态稳定影响失效（化生）时或在两个不同形态稳定场的交界处，癌症发生得更为频繁。本综述将描述我们对形态稳定器和形态稳定的了解，讨论形态稳定破坏在恶性肿瘤中作用的证据，并提出一些可检验的假设。
