Dreyfuss G, Vignoles P, Rondelaud D
UPRES EA no. 3174/USC INRA, Faculties of Pharmacy and Medicine, Université de Limoges, 2, rue du Dr Raymond Marcland, 87025 Limoges, France.
Parasitol Res. 2007 Sep;101(4):1157-60. doi: 10.1007/s00436-007-0580-1. Epub 2007 May 24.
A retrospective study on experimental infections of Galba truncatula, originating from four populations, was carried out to determine the infectivity of Fasciola hepatica miracidia in snails either subjected to single-miracidium or bimiracidial exposures in 2006 and to compare it with results found before 1990 in other experiments using the same protocol. In single-miracidium infections, the prevalence of snail infection was significantly greater in 2006 than in experiments performed before 1980, while snail survival at day 30 postexposure showed insignificant differences. In bimiracidial infections, snail survival in two snail groups was significantly lower in 2006 than in experiments performed from 1981 to 1990, while insignificant differences were found for the other two populations of G. truncatula. Compared to results found between 1981 and 1990, the prevalence of snail infection did not significantly differ in 2006. In each population considered alone, the mean number of cercariae shed by infected snails did not significantly vary, whatever the date of experiment and the number of miracidia used for each exposure. The greater infectivity of F. hepatica miracidia towards snails might be the consequence of specific molecules such as triclabendazole used since 1990 to treat fasciolosis in cattle from central France.
对源自四个种群的截口土蜗进行了实验感染的回顾性研究，以确定2006年单尾蚴或双尾蚴感染的蜗牛中肝片吸虫毛蚴的感染力，并将其与1990年以前使用相同方案的其他实验结果进行比较。在单尾蚴感染中，2006年蜗牛感染率显著高于1980年以前进行的实验，而暴露后30天的蜗牛存活率差异不显著。在双尾蚴感染中，2006年两个蜗牛组的蜗牛存活率显著低于1981年至1990年进行的实验，而另外两个截口土蜗种群差异不显著。与1981年至1990年的结果相比，2006年蜗牛感染率没有显著差异。单独考虑每个种群时，无论实验日期和每次暴露使用的毛蚴数量如何，受感染蜗牛排出的尾蚴平均数量没有显著变化。肝片吸虫毛蚴对蜗牛感染力的增加可能是自1990年以来用于治疗法国中部牛肝片吸虫病的三氯苯达唑等特定分子的结果。
