Pulido-Rivas P, Martínez-Sarries F J, Ochoa M, Sola R G
Unidad de Neurocirugía, Hospital Montepríncipe, Boadilla del Monte, Madrid, España.
Rev Neurol. 2007;44(10):616-24.
The current incidence of intraventricular haemorrhage in low-weight preterm infants is 20%. The percentage of patients who are going to develop hydrocephalus secondary to this haemorrhage varies greatly. In the last 20 years different medical and surgical treatments have been put forward to prevent both the occurrence of haemorrhage and the development of hydrocephalus.
In this study we review the literature on the different treatments used to control and treat hydrocephalus. From the medical point of view, treatment with pharmacological agents such as azetazolamide or furosemide offers more drawbacks than advantages as far as their capacity to prevent hydrocephalus is concerned. Treatments involving fibrinolytic agents offer a high risk of triggering new haemorrhages but in recent years their use has been taken up again in combination with ventricular drains. As regards surgical treatment of hydrocephalus due to haemorrhage, despite the risk of infection, it is more advisable to use ventricular drains than to introduce subgaleal reservoirs. At the present time, the best definitive treatment for hydrocephalus in preterm infants is still the ventriculoperitoneal shunt. The most suitable time is when the weight of the newborn infant exceeds 1500 g and the cerebrospinal fluid offers a protein count above 200 mg/dL.
The long-term neurological development of these children depends mainly on the severity of the haemorrhage, but poorer prognoses are observed in cases in which complications arise from the control examinations of the valve shunt systems.
低体重早产儿脑室内出血的当前发生率为20%。继发于这种出血而发生脑积水的患者百分比差异很大。在过去20年中,已经提出了不同的医学和外科治疗方法来预防出血的发生和脑积水的发展。
在本研究中,我们回顾了有关用于控制和治疗脑积水的不同治疗方法的文献。从医学角度来看,就其预防脑积水的能力而言,使用乙酰唑胺或呋塞米等药物进行治疗弊大于利。涉及纤溶药物的治疗引发新出血的风险很高,但近年来它们又与脑室引流管联合使用。至于因出血导致的脑积水的外科治疗,尽管有感染风险,但使用脑室引流管比引入帽状腱膜下储液器更可取。目前,早产儿脑积水的最佳确定性治疗方法仍然是脑室腹腔分流术。最合适的时机是新生儿体重超过1500克且脑脊液蛋白计数高于200毫克/分升时。
这些儿童的长期神经发育主要取决于出血的严重程度,但在因瓣膜分流系统的控制检查出现并发症的病例中,观察到预后较差。