Colovic Radoje, Grubor Nikica, Micev Marjan, Radak Vladimir
Institute for Digestive Diseases, Clinical Center of Serbia, Belgrade, Serbia and Montenegro.
Hepatogastroenterology. 2007 Mar;54(74):386-8.
Hepatocellular adenoma is a rare benign tumor of the liver which appears almost exclusively in women taking oral contraceptives. Malignant alteration of the tumor is very rare with about 12 reported cases. Case outline. We present a 70-year-old woman who had not taken either oral contraceptive or other hormones ever in her life and in whom an abdominal tumor was discovered during the regular check-up for arterial hypertension. With ultrasonography and CT scan a solitary well demarcated mass within the right liver of otherwise normal appearance was diagnosed. During an open surgery a solitary, unilobular, spherical, well demarcated tumor on the lower surface of the segments IVb, V and VI of the liver, 115 x 100 x 90 mm in diameter was excised. The histology revealed a hepatocellular adenoma with malignant alteration. The patient is the eldest presented case of malignant alteration of hepatocellular adenoma who had never taken oral contraceptives or other hormones.
肝细胞腺瘤是一种罕见的肝脏良性肿瘤，几乎仅见于服用口服避孕药的女性。该肿瘤的恶性转变非常罕见，据报道约有12例。病例概述。我们报告一名70岁女性，她一生中从未服用过口服避孕药或其他激素，在定期高血压检查中发现腹部有肿瘤。通过超声和CT扫描，在外观正常的右肝内诊断出一个边界清晰的孤立肿块。在一次开放手术中，切除了肝脏IVb、V和VI段下表面一个直径为115×100×90mm的孤立、单叶、球形、边界清晰的肿瘤。组织学检查显示为伴有恶性转变的肝细胞腺瘤。该患者是从未服用过口服避孕药或其他激素的肝细胞腺瘤恶性转变患者中年龄最大的。
