75岁及以上患者中的结直肠癌

Colorectal cancer among patients aged 75 years or over.

作者信息

Araujo Sergio Eduardo Alonso, de Paris Caravatto Pedro Paulo, de Campos Fabio Guilherme Caserta Marysael, da Silva e Sousa Alfonso Henrique, Nahas Sergio Carlos, Kiss Desidério Roberto, Cecconello Ivan

机构信息

Colorectal Surgery Division, University of São Paulo Medical School, São Paulo, Brazil.

出版信息

Hepatogastroenterology. 2007 Mar;54(74):427-30.

PMID:17523289

Abstract

BACKGROUND/AIMS: The aim of this study is to evaluate the risk factors for mortality, morbidity, and long-term survival in elderly patients with colorectal cancer when compared to younger patients.

METHODOLOGY

Patients operated on with colorectal cancer were divided into 2 groups according to age: Group 1 (75 years old or older, n=90) and group 2 (<75 years, n=430).

RESULTS

Preoperative hemoglobin levels were lower in group 1 (p = 0.008). Poorer clinical status defined by ASA score (p = 0.008) results and blood transfusions (p = 0.003) were more frequent in group 1 when compared to group 2. Group 1 had a significantly higher operative mortality rate than group 2 (p = 0.01). Regarding cancer-related survival after 1, 2, and 4 years, there was no significant difference between the 2 groups.

CONCLUSIONS

Poorer clinical conditions with special regard to anemia are more frequent among patients of 75 years and older and this finding may lead to an increase in operative mortality when compared to younger patients. Even though, senior patients with colorectal cancer should not be denied surgical and adjuvant therapy on account of age alone since cancer-related survival remains comparable to younger patients' results.

摘要

背景/目的：本研究旨在评估老年结直肠癌患者与年轻患者相比，在死亡率、发病率和长期生存方面的风险因素。

方法

接受结直肠癌手术的患者按年龄分为两组：第1组（75岁及以上，n = 90）和第2组（<75岁，n = 430）。

结果

第1组术前血红蛋白水平较低（p = 0.008）。与第2组相比，第1组中由美国麻醉医师协会（ASA）评分定义的较差临床状态（p = 0.008）以及输血情况（p = 0.003）更为常见。第1组的手术死亡率明显高于第2组（p = 0.01）。关于1年、2年和4年后的癌症相关生存率，两组之间无显著差异。