Sobenin I A, Prianishnikov V V, Kunnova L M, Rabinovich E A, Orekhov A N
Klin Med (Mosk). 2007;85(3):25-8.
The aim of the study was to investigate the effects of allicor (a long-action garlic-based preparation) on the risk of acute myocardial infarction (MI) and sudden death (SD) in patients with coronary artery disease (CAD). Fifty one CAD patients were included in this double-blind placebo-controlled study. The prognostic risk of MI and SD during ten following years was counted using Cox proportional hazards model based on the results of Munster study. Allicor administered for 12 months was demonstrated to reduce absolute ten-year risk of acute MI and SD 1.5 times in men and 1.3 times in women. The reduction in calculated risk parameters was associated with changes in blood plasma lipid profile, the most significant of which was reduction in the level of low density lipoprotein cholesterol (p < 0.05) by 32.9 mg/dl in men and 27.3 mg/dl in women. The results of this study demonstrate that allicor is effective for the reduction of multifactor MI and SD risk as a means of secondary CAD prophylaxis.
该研究的目的是调查蒜精（一种长效大蒜制剂）对冠状动脉疾病（CAD）患者急性心肌梗死（MI）和猝死（SD）风险的影响。51名CAD患者被纳入这项双盲安慰剂对照研究。基于明斯特研究的结果，使用Cox比例风险模型计算接下来十年内心肌梗死和猝死的预后风险。结果表明，服用12个月蒜精可使男性急性心肌梗死和猝死的绝对十年风险降低1.5倍，女性降低1.3倍。计算得出的风险参数降低与血浆脂质谱变化有关，其中最显著的是男性低密度脂蛋白胆固醇水平降低32.9mg/dl（p<0.05），女性降低27.3mg/dl。这项研究的结果表明，蒜精作为CAD二级预防手段，可有效降低多因素心肌梗死和猝死风险。
