Tets G V, Artemenko K L
Antibiot Khimioter. 2006;51(6):3-6.
The impact of DNase on formation of biofilms by grampositive and gramnegative bacteria was studied. The enzyme was shown to inhibit the biofilm formation and have no toxicity to bacteria. When applied to the formed associations, DNase potentiated the effect of antibiotics on the bacteria located in them. An increase in the antimicrobial effect of various nonrelated antibiotics was not connected with a change in the bacteria susceptibility but likely resulted from a break of the genetic cooperation of the cells' community, connected with functions of extracellular DNA of the biofilm's matrix.
研究了脱氧核糖核酸酶（DNase）对革兰氏阳性菌和革兰氏阴性菌生物膜形成的影响。结果表明，该酶可抑制生物膜形成，且对细菌无毒性。当应用于已形成的菌聚体时，DNase可增强抗生素对其中细菌的作用。多种不相关抗生素抗菌效果的增强并非与细菌敏感性的改变有关，而可能是由于生物膜基质细胞外DNA功能相关的细胞群落遗传合作的中断所致。
