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[美西律与非麻醉性镇痛药对动物痛阈和情绪应激行为的联合作用]

[Combined action of mexidol and non-narcotic analgesics on pain thresholds and emotional stress behavior in animals].

作者信息

Molodavkin G M, Voronina T A, Larentsova L I, Pchelkina M I, Meletova O K

出版信息

Eksp Klin Farmakol. 2007 Mar-Apr;70(2):16-9.

Abstract

The influence of non-narcotic analgesics analgin and pentalgin in the basic pharmacological effects of diazepam and mexidol has been studied in outbred male albino rats. It is established that both analgesics do not influence the activity of diazepam. At the same time, they potentiate the analgesic action of mexidol without influencing its antistress action and not inducing any side effects. The strengthening influence of pentalgin was more pronounced. It is concluded that mexidol can be administered in combination with non-narcotic analgesics, in particular with pentalgin, for relieving painful syndrome on the background of stress.

摘要

在远交系雄性白化大鼠中研究了非麻醉性镇痛药安乃近和戊双咪对安定和甲磺酸二甲氨基乙醇基本药理作用的影响。已确定这两种镇痛药均不影响安定的活性。同时,它们增强了甲磺酸二甲氨基乙醇的镇痛作用,而不影响其抗应激作用,也不引起任何副作用。戊双咪的增强作用更为明显。得出结论,甲磺酸二甲氨基乙醇可与非麻醉性镇痛药,特别是与戊双咪联合使用,以缓解应激背景下的疼痛综合征。

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