Tiurenkov I N, Bagmetov M N, Epishina V V
Eksp Klin Farmakol. 2007 Mar-Apr;70(2):24-9.
The neuroprotective properties of phenotropil and piracetam were studied in Wistar rats with low and high sensitivity with respect to cerebral ischemia caused by bilateral irreversible simultaneous occlusion of carotid arteries and gravitational overload in craniocaudal vector. In addition, the effects of both drugs on microcirculation in the brain cortex under ischemic injury conditions were studied. Phenotropil and (to a lower extent) piracetam reduced the extent of neuralgic deficiency manifestations, retained the locomotor, research, and memory functions in animals with gravitational cerebral ischemia, increased the survival of experimental animals, and favored the restoration of local cerebral flow upon the occlusion of carotid arteries.
研究了苯托品和吡拉西坦对Wistar大鼠的神经保护特性，这些大鼠对双侧颈总动脉不可逆同时闭塞和头尾向量重力过载引起的脑缺血具有低敏感性和高敏感性。此外，还研究了两种药物在缺血性损伤条件下对大脑皮层微循环的影响。苯托品和（程度较低的）吡拉西坦减少了神经功能缺损表现的程度，在重力性脑缺血动物中保留了运动、探究和记忆功能，提高了实验动物的存活率，并有利于在颈动脉闭塞时恢复局部脑血流。
