Vengerovskiĭ A I, Khazanov V A
Eksp Klin Farmakol. 2007 Mar-Apr;70(2):51-5.
In the tests on rats with a model of encephalopathy caused by 4-pentenoic acid (inhibitor of the beta-oxidation of fatty acids), the hepatoprotective agent silymarin increases the respiratory activity in brain mitochondria, improves oxidative phosphorylation coupling and energization, and inhibits lipid peroxidation. Succinic acid (a regulator of bioenergetics) improves the damaged Krebs cycle metabolic pathways and produces an antioxidant effect. The combined use of silymarin and succinic demonstrated more expressed cerebroprotective action as compared to that of each agent administered separately.
在对由4-戊烯酸（脂肪酸β-氧化抑制剂）引起的脑病模型大鼠进行的试验中，肝保护剂水飞蓟宾可提高脑线粒体中的呼吸活性，改善氧化磷酸化偶联和供能，并抑制脂质过氧化。琥珀酸（一种生物能量调节剂）可改善受损的三羧酸循环代谢途径并产生抗氧化作用。与单独使用每种药物相比，水飞蓟宾和琥珀酸联合使用表现出更明显的脑保护作用。
