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Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.

作者信息

Shirude Pravin S, Okumus Burak, Ying Liming, Ha Taekjip, Balasubramanian Shankar

机构信息

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

出版信息

J Am Chem Soc. 2007 Jun 20;129(24):7484-5. doi: 10.1021/ja070497d. Epub 2007 May 25.

DOI:10.1021/ja070497d
PMID:17523641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2195893/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/15c0e6fc9ac0/nihms-1356-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/b4d206c7189c/nihms-1356-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/de00a6bf1db7/nihms-1356-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/e1902a9e8bc4/nihms-1356-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/72fd632c4316/nihms-1356-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/15c0e6fc9ac0/nihms-1356-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/b4d206c7189c/nihms-1356-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/de00a6bf1db7/nihms-1356-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/e1902a9e8bc4/nihms-1356-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/72fd632c4316/nihms-1356-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea2/2195893/15c0e6fc9ac0/nihms-1356-f0005.jpg

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本文引用的文献

1
G-quadruplexes in promoters throughout the human genome.人类基因组中启动子区域的G-四链体
Nucleic Acids Res. 2007;35(2):406-13. doi: 10.1093/nar/gkl1057. Epub 2006 Dec 14.
2
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.位于人类c-kit癌基因转录激活位点的一个保守四链体基序。
Biochemistry. 2006 Jun 27;45(25):7854-60. doi: 10.1021/bi0601510.
3
Spectral identification of specific photophysics of cy5 by means of ensemble and single molecule measurements.通过系综和单分子测量对Cy5特定光物理性质进行光谱鉴定。
J Phys Chem A. 2006 Jan 12;110(1):45-50. doi: 10.1021/jp0562936.
4
Extreme conformational diversity in human telomeric DNA.人类端粒DNA中存在极端的构象多样性。
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18938-43. doi: 10.1073/pnas.0506144102. Epub 2005 Dec 19.
5
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo.端粒末端结合蛋白在体内控制G-四链体DNA结构的形成。
Nat Struct Mol Biol. 2005 Oct;12(10):847-54. doi: 10.1038/nsmb982. Epub 2005 Sep 4.
6
Prevalence of quadruplexes in the human genome.人类基因组中四链体的患病率。
Nucleic Acids Res. 2005 May 24;33(9):2908-16. doi: 10.1093/nar/gki609. Print 2005.
7
Vesicle encapsulation studies reveal that single molecule ribozyme heterogeneities are intrinsic.囊泡包封研究表明，单分子核酶的异质性是内在的。
Biophys J. 2004 Oct;87(4):2798-806. doi: 10.1529/biophysj.104.045971.
8
Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter.人类c-myc启动子中的螺旋桨型平行链G-四链体
J Am Chem Soc. 2004 Jul 21;126(28):8710-6. doi: 10.1021/ja048805k.
9
Structural dynamics and processing of nucleic acids revealed by single-molecule spectroscopy.单分子光谱揭示的核酸结构动力学与加工过程
Biochemistry. 2004 Apr 13;43(14):4055-63. doi: 10.1021/bi049973s.
10
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.通过单分子荧光共振能量转移对人类端粒G-四链体的结构与动力学进行的研究。
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14629-34. doi: 10.1073/pnas.2433350100. Epub 2003 Nov 25.