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整体和单分子 FRET 分析 c-kit 启动子四联体的结构和展开动力学。

Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.

机构信息

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.

出版信息

Chem Commun (Camb). 2010 Feb 14;46(6):946-8. doi: 10.1039/b920680a. Epub 2009 Dec 10.

DOI:10.1039/b920680a
PMID:20107659
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3044463/
Abstract

FRET analysis has been used to examine the folded conformations and differing kinetic stabilities of two DNA G-quadruplexes (c-kit 1 and c-kit 2) derived from sequences found in the promoter of the c-kit proto-oncogene.

摘要

荧光共振能量转移分析已被用于研究两种源自 c-kit 原癌基因启动子序列的 DNA G-四链体（c-kit 1 和 c-kit 2）的折叠构象和不同的动力学稳定性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f063/3044463/6493d82305ae/ukmss-34276-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f063/3044463/60423284b4c4/ukmss-34276-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f063/3044463/b33b5034edeb/ukmss-34276-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f063/3044463/6493d82305ae/ukmss-34276-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f063/3044463/60423284b4c4/ukmss-34276-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f063/3044463/b33b5034edeb/ukmss-34276-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f063/3044463/6493d82305ae/ukmss-34276-f0003.jpg

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本文引用的文献

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J Am Chem Soc. 2009 Sep 23;131(37):13399-409. doi: 10.1021/ja904007p.
2
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.用一种四链体结合小分子靶向人类胃肠道间质瘤细胞。
J Med Chem. 2009 Jun 25;52(12):3774-83. doi: 10.1021/jm900424a.
3
The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.负超螺旋在诱导c-Myc启动子中G-四链体和i-基序结构形成中的重要性：对药物靶向和基因表达调控的意义。
J Med Chem. 2009 May 14;52(9):2863-74. doi: 10.1021/jm900055s.
4
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression.三取代异咯嗪作为一类新型的G-四链体结合配体：c-kit癌基因表达的小分子调控
J Am Chem Soc. 2007 Oct 31;129(43):12926-7. doi: 10.1021/ja075881p. Epub 2007 Oct 5.
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