Huang Xianhai, Shao Ning, Palani Anandan, Aslanian Robert, Buevich Alexei
Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.
Org Lett. 2007 Jun 21;9(13):2597-600. doi: 10.1021/ol071068n. Epub 2007 May 25.
The total synthesis of a new member of the pederin family of natural products, psymberin 1, was accomplished. Using a recently reported novel and efficient PhI(OAc)2 mediated oxidative entry to 2-(N-acylaminal)-substituted tetrahydropyrans as the key step, this total synthesis was executed in a convergent and efficient manner. The longest linear sequence of this synthesis was 22 steps starting from known 6.
天然产物海兔毒素家族新成员——海兔素1的全合成得以实现。该全合成以最近报道的一种新颖且高效的由二醋酸碘苯介导的氧化反应构建2-(N-酰氨基)-取代四氢吡喃为关键步骤，以汇聚式且高效的方式完成。此合成中最长的线性序列从已知化合物6开始为22步。
