Surry David S, Buchwald Stephen L
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. ; Tel: +1-617-253-1885.
Chem Sci. 2010;1(1):13-31. doi: 10.1039/C0SC00107D.
The utility of copper-mediated cross-coupling reactions has been significantly increased by the development of mild reaction conditions and the ability to employ catalytic amounts of copper. The use of diamine-based ligands has been important in these advances and in this review we discuss these systems, including the choice of reaction conditions and applications in the synthesis of pharmaceuticals, natural products and designed materials.
温和反应条件的开发以及使用催化量铜的能力显著提高了铜介导的交叉偶联反应的实用性。基于二胺的配体的使用在这些进展中起到了重要作用,在本综述中,我们将讨论这些体系,包括反应条件的选择以及在药物、天然产物和设计材料合成中的应用。