Daugule Ilva, Rumba Ingrida, Alksnis Janis, Ejderhamn Jan
Faculty of Medicine, University of Latvia, Riga, Latvia.
Acta Paediatr. 2007 Jul;96(7):1047-9. doi: 10.1111/j.1651-2227.2007.00329.x. Epub 2007 May 24.
To investigate the link between H.pylori infection and dyspepsia in children, and association with reflux oesophagitis.
H.pylori status was detected by rapid urease test and/or culture in 130 consecutive symptomatic children coming for upper gastrointestinal endoscopy: 40 - aged 8-12 years (55% boys); 90 - aged 13-18 years (21% boys). Endoscopic findings were analyzed. H.pylori prevalence in the age group 8-12 years was compared to the prevalence among 55 asymptomatic children, aged 7-12 years (13C-urea breath test).
chi(2) test, Fisher's test, and logistic regression analysis.
The prevalence of H.pylori infection among patients with gastrointestinal symptoms was 54%. It was significantly higher among patients with reflux oesophagitis compared to patients with hyperaemic gastropathy: OR = 5.5; p = 0.03, 95% CI: 1.15-26.3. In logistic regression analysis, no significant difference between the prevalence of H.pylori infection between asymptomatic and symptomatic children could be demonstrated (OR = 1.8; 95% CI: 0.62-5.14).
The prevalence of H.pylori was significantly higher among patients with reflux oesophagitis compared to patients with hyperaemic gastropathy alone. Adjusting for age the prevalence of H.pylori infection was not higher among symptomatic children compared to asymptomatic children of the same age.
探讨幽门螺杆菌（H.pylori）感染与儿童消化不良之间的联系，以及与反流性食管炎的相关性。
对130例因上消化道内镜检查前来就诊的有症状儿童进行快速尿素酶试验和/或培养，以检测H.pylori感染情况：40例年龄在8至12岁（男孩占55%）；90例年龄在13至18岁（男孩占21%）。对内镜检查结果进行分析。将8至12岁年龄组的H.pylori感染率与55例7至12岁无症状儿童（13C尿素呼气试验）的感染率进行比较。
采用卡方检验、Fisher检验和逻辑回归分析。
胃肠道症状患者中H.pylori感染率为54%。与充血性胃病患者相比，反流性食管炎患者中的感染率显著更高：比值比（OR）=5.5；p = 0.03，95%置信区间（CI）：1.15 - 26.3。在逻辑回归分析中，无症状和有症状儿童之间的H.pylori感染率无显著差异（OR = 1.8；95% CI：0.62 - 5.14）。
与单纯充血性胃病患者相比，反流性食管炎患者中H.pylori感染率显著更高。校正年龄后，有症状儿童的H.pylori感染率与同年龄无症状儿童相比并无更高。
