考虑肝脏状况的埃及成年人的雄激素谱。

Androgen profiles among Egyptian adults considering liver status.

作者信息

Aguilar Cristina E, Soliman Amr S, McConnell Daniel S, Zekri Abdel-Rahman, Banerjee Mousumi, Omar Ayman, Sharawy Mohamed, Omar Sherif, Raouf Ahmed, Sowers Maryfran R

机构信息

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA.

出版信息

J Gastroenterol Hepatol. 2008 Jul;23(7 Pt 2):e137-45. doi: 10.1111/j.1440-1746.2007.04949.x. Epub 2007 May 24.

DOI:10.1111/j.1440-1746.2007.04949.x

PMID:17524040

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4275097/

Abstract

BACKGROUND AND AIM

Hepatitis C virus (HCV) and environmental hepatotoxins may have an indirect influence on health by altering the synthesis and function of hormones, particularly reproductive hormones. We aimed to evaluate liver diseases and sex steroid hormones in Egypt, which has the highest prevalence of HCV worldwide.

METHODS

We measured markers of hepatitis B virus (HBV), HCV and schistosomiasis infection as well as liver function in 159 apparently healthy subjects. We measured total testosterone (T), sex-hormone binding globulin (SHBG) and albumin, and calculated the free androgen index.

RESULTS

Anti-HCV antibodies were detected in 51% of men and 42% of women. Based on HCV reverse transcription PCR (RT-PCR) of 44 men and 33 women, 11% of men and 21% of women showed HCV viremia. There was schistosomiasis in 25% of men and 9% of women, and mixed HCV viremia and schistosomiasis in 57% of men and 52% of women. Compared with men with schistosomiasis only (mean 593.3 +/- 73.4 ng/dL), T was higher in men with mixed HCV viremia and schistosomiasis (mean 854.5 +/- 47.9 ng/dL; P = 0.006) and men with mixed chronic HCV and schistosomiasis (mean 812.1 +/- 43.3 ng/dL; P = 0.001). Men with mixed chronic HCV and schistosomiasis had also significantly higher SHBG (mean 57.7 +/- 3.9 ng/dL) than males with schistosomiasis only (mean 34.8 +/- SE 4.5 ng/dL; P = 0.0003).

CONCLUSION

Future investigations should consider that a high prevalence of asymptomatic liver disease may alter associations between hormone concentrations and chronic disease etiology.

摘要

背景与目的

丙型肝炎病毒（HCV）和环境肝毒素可能通过改变激素尤其是生殖激素的合成与功能，对健康产生间接影响。我们旨在评估在全球HCV患病率最高的埃及的肝脏疾病和性类固醇激素情况。

方法

我们检测了159名表面健康受试者的乙型肝炎病毒（HBV）、HCV和血吸虫病感染标志物以及肝功能。我们测量了总睾酮（T）、性激素结合球蛋白（SHBG）和白蛋白，并计算了游离雄激素指数。

结果

51%的男性和42%的女性检测出抗HCV抗体。基于对44名男性和33名女性的HCV逆转录聚合酶链反应（RT-PCR），11%的男性和21%的女性出现HCV病毒血症。25%的男性和9%的女性患有血吸虫病，57%的男性和52%的女性同时存在HCV病毒血症和血吸虫病。与仅患有血吸虫病的男性（平均593.3±73.4 ng/dL）相比，同时患有HCV病毒血症和血吸虫病的男性（平均854.5±47.9 ng/dL；P = 0.006）以及同时患有慢性HCV和血吸虫病的男性（平均812.1±43.3 ng/dL；P = 0.001）的T水平更高。同时患有慢性HCV和血吸虫病的男性的SHBG水平（平均57.7±3.9 ng/dL）也显著高于仅患有血吸虫病的男性（平均34.8±标准误4.5 ng/dL；P = 0.0003）。