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ST段抬高型心肌梗死直接经皮冠状动脉介入治疗后临床结局的种族差异:医疗过程的影响

Racial disparity in clinical outcomes following primary percutaneous coronary intervention for ST elevation myocardial infarction: influence of process of care.

作者信息

Jacobi Joshua A, Parikh Shailja V, McGuire Darren K, Delemos James A, Murphy Sabina A, Keeley Ellen C

机构信息

University of Texas Southwestern Medical Center, Dallas, TX, USA.

出版信息

J Interv Cardiol. 2007 Jun;20(3):182-7. doi: 10.1111/j.1540-8183.2007.00263.x.

DOI:10.1111/j.1540-8183.2007.00263.x
PMID:17524109
Abstract

Previous studies have shown that compared with white patients, non-white patients with ST elevation myocardial infarction (STEMI) have worse clinical outcomes. Differences in co-morbidities, extent and severity of coronary artery disease, health insurance, and socioeconomic status have been identified as possible reasons for this disparity. However, an alternative explanation for such observed disparities in outcomes could be differences in process of care. For example, in most of these studies, non-white patients were less likely to receive reperfusion therapy, and if treated, were more likely to receive thrombolysis than to undergo primary percutaneous coronary intervention (PCI). We hypothesized that if all patients were treated similarly with primary PCI, there would be no difference in clinical outcomes. We analyzed the demographic, angiographic, in-hospital clinical outcomes, and long-term mortality rates of a racially diverse group of patients presenting to the same hospital with STEMI, all of whom were treated with primary PCI. Our data demonstrate that compared with white patients, non-white patients with STEMI who undergo primary PCI have similar in-hospital clinical outcomes and one-year mortality. This suggests that the previously observed differences in mortality rates may be, at least in part, attributable to differences in the process of care, and not solely to differences in patient factors or differential therapeutic effects.

摘要

先前的研究表明,与白人患者相比,非白人ST段抬高型心肌梗死(STEMI)患者的临床结局更差。合并症、冠状动脉疾病的范围和严重程度、医疗保险以及社会经济地位的差异已被确定为这种差异的可能原因。然而,对于观察到的这种结局差异的另一种解释可能是医疗过程的差异。例如,在大多数这些研究中,非白人患者接受再灌注治疗的可能性较小,并且如果接受治疗,与接受直接经皮冠状动脉介入治疗(PCI)相比,更有可能接受溶栓治疗。我们假设,如果所有患者都接受类似的直接PCI治疗,临床结局将不会有差异。我们分析了同一医院因STEMI就诊的不同种族患者群体的人口统计学、血管造影、住院临床结局和长期死亡率,所有这些患者均接受了直接PCI治疗。我们的数据表明,与白人患者相比,接受直接PCI治疗的非白人STEMI患者具有相似的住院临床结局和一年死亡率。这表明,先前观察到的死亡率差异可能至少部分归因于医疗过程的差异,而不仅仅是患者因素或治疗效果差异。

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