Medina-Lezama Josefina, Zea-Diaz Humberto, Morey-Vargas Oscar L, Bolaños-Salazar Juan F, Muñoz-Atahualpa Edgar, Postigo-MacDowall Mauricio, Corrales-Medina Fernando, Valdivia-Ascuña Zoila, Cuba-Bustinza Carolina, Paredes-Díaz Sheyla, Villalobos-Tapia Paola, Chirinos-Pacheco Julio, Goldberg Ronald B, Chirinos Julio A
Santa Maria Catholic University School of Medicine and Santa Maria Research Institute, Arequipa, Peru.
Diabetes Res Clin Pract. 2007 Nov;78(2):270-81. doi: 10.1016/j.diabres.2007.04.004. Epub 2007 May 23.
Data regarding the prevalence of metabolic syndrome (MTS) in Andean populations are limited. We evaluated the prevalence of MTS according to American Heart Association/National Heart, Lung and Blood Institute criteria among 1878 subjects in the PREVENCION study in Peru. In women, the most common component was low HDL cholesterol (60.9%) followed by abdominal obesity (36.9%). In men, the most common component was elevated triglycerides (52.0%) followed by low HDL cholesterol (32.5%), whereas the prevalence of abdominal obesity was 14%. Abnormal fasting glucose was the least common component in men (5.4%) and women (5.0%). The prevalence of MTS was significantly higher in women compared to men (23.2% versus 14.3%) and increased steeply with age, particularly in women (p<0.0001). Using body mass index (BMI>or=30kg/m2) instead of waist circumference as a component of the MTS lead to equivalent prevalence estimates of MTS in men but significantly underestimated the prevalence in women. The MTS is highly prevalent among Peruvian Andeans, particularly in older women. The pattern of MTS components in this Andean population is characterized by a high prevalence of dyslipidemia and a relatively low prevalence of elevated fasting glucose. Further studies are required to characterize genetic and environmental determinants of these patterns.
关于安第斯人群代谢综合征（MTS）患病率的数据有限。我们根据美国心脏协会/美国国立心肺血液研究所的标准，对秘鲁PREVENCION研究中的1878名受试者的MTS患病率进行了评估。在女性中，最常见的组分是高密度脂蛋白胆固醇水平低（60.9%），其次是腹型肥胖（36.9%）。在男性中，最常见的组分是甘油三酯升高（52.0%），其次是高密度脂蛋白胆固醇水平低（32.5%），而腹型肥胖的患病率为14%。空腹血糖异常是男性（5.4%）和女性（5.0%）中最不常见的组分。女性的MTS患病率显著高于男性（23.2%对14.3%），并且随年龄急剧增加，尤其是在女性中（p<0.0001）。使用体重指数（BMI≥30kg/m2）而非腰围作为MTS的一个组分，得出的男性MTS患病率估计值相当，但显著低估了女性的患病率。MTS在秘鲁安第斯人群中非常普遍，尤其是在老年女性中。该安第斯人群中MTS组分的模式特点是血脂异常患病率高，而空腹血糖升高的患病率相对较低。需要进一步研究来确定这些模式的遗传和环境决定因素。
