Suárez-Cuenca Juan A, Díaz-Jiménez Diana Elisa, Pineda-Juárez Juan A, Mendoza-Mota Alondra Gissel, Valencia-Aldana Ofelia Dinora, Núñez-Angeles Said, Vera-Gómez Eduardo, Hernández-Patricio Alejandro, Loeza-Magaña Pavel, Lara-Vargas Jorge Antonio, Arteaga-Martínez José Rodolfo, Garduño-Pérez Ángel Alfonso, Montoya-Ramírez Jesús, Díaz-Aranda María Angélica, Chaparro-Hernández Roberto Carlos, Melchor-López Alberto, García Silvia, Gutiérrez-Salinas José, Mondragón-Terán Paul
Laboratory of Experimental Metabolism and Clinical Research, CMN "20 de Noviembre", ISSSTE. San Lorenzo 503, Col. Del Valle, Alcaldía Benito Juárez, Mexico City 03100, Mexico.
Hospital General de Zona No. 32 "Dr. Mario Madrazo Navarro", Instituto Mexicano del Seguro Social, Calzada del Hueso S/N, Col. Santa Úrsula Coapa, Alcaldía Coyoacán, Mexico City 04980, Mexico.
Nutrients. 2025 Jan 11;17(2):256. doi: 10.3390/nu17020256.
Metabolic syndrome (MS) is a combination of comorbidities that increase pro-inflammatory cytokines (PIC) production, with subsequent body composition (BC) abnormalities and high cardiovascular risk. Treatment with diet and exercise has been suggested as possible non-pharmacological adjuvant treatment.
To determine changes in BC and PIC in patients with MS after a Mediterranean-type diet (MedDiet) and/or isokinetic exercise (IE).
A controlled randomized clinical trial was conducted at a third-level hospital in Mexico City. Intervention groups: G1: MedDiet + IE; G2: IE; G3: MedDiet; G4: control. Anthropometry, BC, and PIC were collected from the baseline and at 12 weeks post-intervention. MedDiet was estimated from a 24-h recall record. IE consisted of a standard high-intensity anaerobic exercise program.
Forty-two patients with MS aged 18-65 years old were included. The most frequent comorbidities were obesity, insulin resistance, and dyslipidemia. After 6 months of intervention, a significant reduction of resistin was observed within the IE group and MedDiet + IE, whereas the former group also showed an increase in adiponectin. Interventions of MedDiet and MedDiet + IE showed a decrease in IL-10. Regarding BC, all groups increased the resistance values in relation to the baseline but were lower than the control group.
The results suggest that MedDiet and IE have a selective impact on pro-inflammatory mediators, while the combination of MedDiet and IE may induce only minor changes in BC.
代谢综合征（MS）是多种合并症的组合，这些合并症会增加促炎细胞因子（PIC）的产生，继而导致身体成分（BC）异常和心血管疾病风险升高。饮食和运动治疗被认为是可能的非药物辅助治疗方法。
确定采用地中海式饮食（MedDiet）和/或等速运动（IE）后，MS患者的BC和PIC变化。
在墨西哥城的一家三级医院进行了一项对照随机临床试验。干预组：G1：MedDiet + IE；G2：IE；G3：MedDiet；G4：对照组。在基线和干预后12周收集人体测量数据、BC和PIC。通过24小时回忆记录评估MedDiet。IE包括一个标准的高强度无氧运动项目。
纳入了42名年龄在18 - 65岁的MS患者。最常见的合并症是肥胖、胰岛素抵抗和血脂异常。干预6个月后，IE组和MedDiet + IE组的抵抗素显著降低，而前一组的脂联素也有所增加。MedDiet和MedDiet + IE干预显示IL - 10降低。关于BC，所有组相对于基线的阻力值均增加，但低于对照组。
结果表明，MedDiet和IE对促炎介质有选择性影响，而MedDiet和IE的组合可能仅引起BC的微小变化。
