• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.

作者信息

Wang Yonghui, Busch-Petersen Jakob, Wang Feng, Ma Lanping, Fu Wei, Kerns Jeffrey K, Jin Jian, Palovich Michael R, Shen Jing-Kang, Burman Miriam, Foley James J, Schmidt Dulcie B, Hunsberger Gerald E, Sarau Henry M, Widdowson Katherine L

机构信息

Discovery Medicinal Chemistry, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.

出版信息

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3864-7. doi: 10.1016/j.bmcl.2007.05.011. Epub 2007 May 10.

DOI:10.1016/j.bmcl.2007.05.011
PMID:17524641
Abstract

A series of 3-arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides were prepared and shown to be novel and selective antagonists of the CXCR2 receptor. Synthesis, structure and activity relationships, selectivity, and some developability properties are described.

摘要

相似文献

1
3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.
Bioorg Med Chem Lett. 2007 Jul 15;17(14):3864-7. doi: 10.1016/j.bmcl.2007.05.011. Epub 2007 May 10.
2
Synthesis and structure-activity relationships of 3,4-diaminocyclobut-3-ene-1,2-dione CXCR2 antagonists.3,4-二氨基环丁-3-烯-1,2-二酮CXCR2拮抗剂的合成及其构效关系
Bioorg Med Chem Lett. 2006 Aug 1;16(15):4107-10. doi: 10.1016/j.bmcl.2006.04.082. Epub 2006 May 11.
3
3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.3,4-二氨基-1,2,5-噻二唑作为强效和选择性CXCR2拮抗剂。
Bioorg Med Chem Lett. 2009 Mar 1;19(5):1434-7. doi: 10.1016/j.bmcl.2009.01.027. Epub 2009 Jan 15.
4
Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.新型3-氨基-4-肼基环丁-3-烯-1,2-二酮作为强效和选择性CXCR2趋化因子受体拮抗剂的设计、合成及评估
Bioorg Med Chem Lett. 2009 Oct 1;19(19):5741-5. doi: 10.1016/j.bmcl.2009.08.014. Epub 2009 Aug 7.
5
SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction.
Bioorg Med Chem Lett. 2007 May 15;17(10):2731-4. doi: 10.1016/j.bmcl.2007.02.080. Epub 2007 Mar 3.
6
Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists.新型含二取代苯基的3,4-二氨基-3-环丁烯-1,2-二酮作为CXCR2受体拮抗剂的合成及构效关系
Bioorg Med Chem Lett. 2008 Mar 15;18(6):1864-8. doi: 10.1016/j.bmcl.2008.02.010. Epub 2008 Feb 10.
7
Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor.羧酸生物电子等排体酰基磺酰胺、酰基磺胺和磺酰脲类作为新型CXCR2受体拮抗剂
Bioorg Med Chem Lett. 2008 Mar 15;18(6):1926-30. doi: 10.1016/j.bmcl.2008.01.127. Epub 2008 Feb 7.
8
N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.N,N'-二芳基氰基胍作为CXCR2和CXCR1趋化因子受体的拮抗剂。
Bioorg Med Chem Lett. 2006 Nov 1;16(21):5513-6. doi: 10.1016/j.bmcl.2006.08.042. Epub 2006 Aug 24.
9
Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists.杂芳基取代的3,4-二氨基-3-环丁-3-烯-1,2-二酮CXCR2/CXCR1受体拮抗剂的合成及构效关系
Bioorg Med Chem Lett. 2008 Feb 15;18(4):1318-22. doi: 10.1016/j.bmcl.2008.01.024. Epub 2008 Jan 11.
10
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists.3,4-二氨基-2,5-噻二唑-1-氧化物作为强效CXCR2/CXCR1拮抗剂
Bioorg Med Chem Lett. 2008 Jan 1;18(1):228-31. doi: 10.1016/j.bmcl.2007.10.094. Epub 2007 Oct 30.

引用本文的文献

1
Exploration of Pyrido[3,4-]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2.探索吡啶并[3,4-]嘧啶作为人趋化因子受体 CXCR2 的拮抗剂。
Molecules. 2023 Feb 23;28(5):2099. doi: 10.3390/molecules28052099.
2
Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents.基于配体的药效团模型用于发现新型CXCR2拮抗剂作为抗癌转移剂。
R Soc Open Sci. 2018 Jul 4;5(7):180176. doi: 10.1098/rsos.180176. eCollection 2018 Jul.
3
Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides.
通过分子内钯催化叔磺酰胺的芳基化反应合成苯并稠合磺内酰胺
Beilstein J Org Chem. 2017 Sep 12;13:1932-1939. doi: 10.3762/bjoc.13.187. eCollection 2017.
4
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases.CXCL8-CXCR1/2轴在癌症和炎症性疾病中的作用。
Theranostics. 2017 Apr 7;7(6):1543-1588. doi: 10.7150/thno.15625. eCollection 2017.
5
Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/intramolecular aza-Wittig reaction.通过串联酰胺化/分子内氮杂-Wittig 反应，简便合成苯并噻二嗪 1,1-二氧化物，雷帕霉素合成抑制剂的前体。
Beilstein J Org Chem. 2013 Mar 8;9:503-9. doi: 10.3762/bjoc.9.54. Print 2013.
6
Microwave-assisted sequential one-pot protocol to benzothiadiazin-3-one-1,1-dioxides via a copper-catalyzed N-arylation strategy.通过铜催化的N-芳基化策略，采用微波辅助顺序一锅法合成苯并噻二嗪-3-酮-1,1-二氧化物。
Tetrahedron Lett. 2009 Dec 16;50(50):6935-6937. doi: 10.1016/j.tetlet.2009.09.090.