Tomé João P C, Silva Eduarda M P, Pereira Ana M V M, Alonso Cristina M A, Faustino Maria A F, Neves Maria G P M S, Tomé Augusto C, Cavaleiro José A S, Tavares Sabina A P, Duarte Ricardo R, Caeiro Maria F, Valdeira Maria L
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Bioorg Med Chem. 2007 Jul 15;15(14):4705-13. doi: 10.1016/j.bmc.2007.05.005. Epub 2007 May 6.
Neutral and cationic tripyridylporphyrin-D-galactose conjugates were synthesized and their antiviral activity against herpes simplex virus type 1 (HSV-1) was evaluated. At non-cytotoxic concentrations the studied compounds show significant antiviral activity after photoactivation. The influence of photoactivation on drug treated cells was also analyzed, at different times of infection with HSV-1, for a neutral (1b) and a cationic glycoporphyrin (3b) derivative. The results show that the inhibition of the viral yield is more dependent on photoactivation for compound 1b than for compound 3b. These two compounds also differ in the inhibitory effect during the viral replicative cycle: while compound 3b inhibits the viral yield at all the addition times assayed, compound 1b is more efficient in later times of infection.
合成了中性和阳离子三联吡啶卟啉 - D - 半乳糖共轭物，并评估了它们对1型单纯疱疹病毒（HSV - 1）的抗病毒活性。在无细胞毒性浓度下，所研究的化合物在光激活后显示出显著的抗病毒活性。还分析了光激活对药物处理细胞的影响，在感染HSV - 1的不同时间，针对一种中性（1b）和一种阳离子糖卟啉（3b）衍生物进行了研究。结果表明，对于化合物1b，病毒产量的抑制比化合物3b更依赖于光激活。这两种化合物在病毒复制周期中的抑制作用也有所不同：虽然化合物3b在所有测定的添加时间都能抑制病毒产量，但化合物1b在感染后期更有效。
