Montanha J A, Amoros M, Boustie J, Girre L
Laboratoire de Pharmacognosie et Mycologie, Faculté de Pharmacie, Rennes, France.
Planta Med. 1995 Oct;61(5):419-24. doi: 10.1055/s-2006-958128.
We evaluated, in cell cultures, the action of a series of 19 aporphine alkaloids against Herpes simplex virus type 1 (HSV-1). On the basis of viral titre reduction, six alkaloids were found to be active. The mode of action of the three most potent inhibitors, oliverine HCl, pachystaudine, and oxostephanine, was studied. These compounds did not have any virucidal or prophylactic effect but they were shown to interfere with the viral replicative cycle. Although DNA synthesis was reduced, their exact target remains to be elucidated. In the discussion, some structure-activity relationships are considered.
我们在细胞培养中评估了一系列19种阿朴啡生物碱对1型单纯疱疹病毒（HSV-1）的作用。基于病毒滴度降低，发现6种生物碱具有活性。研究了三种最有效的抑制剂盐酸奥利文、厚壳桂定和氧化士的宁的作用方式。这些化合物没有任何杀病毒或预防作用，但显示出会干扰病毒复制周期。虽然DNA合成减少，但其确切靶点仍有待阐明。在讨论中，考虑了一些构效关系。
