Dines Joshua S, Grande Daniel A, Dines David M
Kerlan Jobe Orthopaedic Foundation, Los Angeles, CA 90045, USA.
J Shoulder Elbow Surg. 2007 Sep-Oct;16(5 Suppl):S204-7. doi: 10.1016/j.jse.2007.03.004. Epub 2007 May 23.
Rotator cuff tears are common soft-tissue injuries that often require surgical treatment. Initial efforts to better tendon healing centered on improving the strength of the repair. More recent studies have focused on biologic enhancement of the healing process. Tissue engineering is a multidisciplinary field that involves the application of scientific principles toward creating living tissue to replace, repair, or augment diseased tissue. Gene therapy involves the transfer of a certain gene into a cell so that the cell translates the gene into a specific protein. The advantage of using a gene-therapy, tissue-engineered approach to effect healing rests in the ability of the physician to select growth factors with documented roles in the tendon-healing cascade. Ideally, an improvement to the current repair technique would yield improved tendon healing leading to improved clinical results.
肩袖撕裂是常见的软组织损伤，通常需要手术治疗。早期改善肌腱愈合的努力主要集中在提高修复强度上。最近的研究则聚焦于愈合过程的生物增强。组织工程是一个多学科领域，涉及应用科学原理来创建活组织，以替代、修复或增强病变组织。基因治疗是将特定基因导入细胞，使细胞将该基因转化为特定蛋白质。采用基因治疗、组织工程方法促进愈合的优势在于医生能够选择在肌腱愈合级联反应中有明确作用的生长因子。理想情况下，对当前修复技术的改进将促进肌腱更好地愈合，从而带来更好的临床效果。
