Olkowski A A, Nain S, Wojnarowicz C, Laarveld B, Alcorn J, Ling B B
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK, Canada.
Comp Biochem Physiol A Mol Integr Physiol. 2007 Sep;148(1):230-8. doi: 10.1016/j.cbpa.2007.04.015. Epub 2007 Apr 22.
In order to explain the biochemical mechanisms associated with deteriorating heart function in broiler chickens, this study compared myocardial high energy phosphate substrates in leghorns, feed restricted (Broilers-Res) broilers, ad libitum fed broilers (Broilers-AL), and in broilers that developed heart failure and ascites. The profile of adenine nucleotide content in the heart tissue did not differ between leghorns and Broilers-Res, but there were significant differences among Broilers-Res, Broilers-AL, and broilers with ascites. During intensive growth periods, leghorns and Broilers-Res showed increasing trends in heart ATP levels, whereas in fast growing broilers the heart ATP declined (p<0.021). ATP:ADP and ATP:CrP ratios increased with age in both leghorn and Broilers-Res, declined in fast growing broilers, and were the lowest in broilers that developed heart failure. The changes in heart high energy phosphate profile in broilers suggest that the energy demand of the heart during a rapid growth phase may exceed the bird's metabolic capacity to supply adequate levels of high energy phosphate substrate. The insufficiency of energy substrate likely contributes to the declining heart rate. In some individuals this may lead to impaired heart pump function, and in more severe cases may progress to heart pump failure.
为了解释肉仔鸡心脏功能恶化相关的生化机制，本研究比较了来航鸡、限饲肉仔鸡（Broilers-Res）、自由采食肉仔鸡（Broilers-AL）以及发生心力衰竭和腹水的肉仔鸡的心肌高能磷酸底物。来航鸡和限饲肉仔鸡心脏组织中的腺嘌呤核苷酸含量分布无差异，但限饲肉仔鸡、自由采食肉仔鸡和有腹水的肉仔鸡之间存在显著差异。在快速生长阶段，来航鸡和限饲肉仔鸡的心脏ATP水平呈上升趋势，而快速生长的肉仔鸡心脏ATP水平下降（p<0.021）。来航鸡和限饲肉仔鸡的ATP:ADP和ATP:CrP比值均随年龄增长而增加，快速生长的肉仔鸡则下降，且在发生心力衰竭的肉仔鸡中最低。肉仔鸡心脏高能磷酸分布的变化表明，快速生长阶段心脏的能量需求可能超过鸡提供足够水平高能磷酸底物的代谢能力。能量底物不足可能导致心率下降。在一些个体中，这可能导致心脏泵功能受损，并在更严重的情况下发展为心脏泵衰竭。
