计算蛋白质设计：结构、功能与组合多样性。

Computational protein design: structure, function and combinatorial diversity.

作者信息

Kang Seung-gu, Saven Jeffery G

机构信息

Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.

出版信息

Curr Opin Chem Biol. 2007 Jun;11(3):329-34. doi: 10.1016/j.cbpa.2007.05.006. Epub 2007 May 23.

DOI:10.1016/j.cbpa.2007.05.006

PMID:17524729

Abstract

Computational protein design has blossomed with the development of methods for addressing the complexities involved in specifying the structure, sequence and function of proteins. Recent applications include the design of novel functional membrane and soluble proteins, proteins incorporating non-biological components and protein combinatorial libraries.

摘要

随着用于解决蛋白质结构、序列和功能确定过程中所涉及复杂性的方法的发展，计算蛋白质设计蓬勃发展。近期的应用包括新型功能性膜蛋白和可溶性蛋白的设计、包含非生物成分的蛋白质设计以及蛋白质组合文库的设计。