Frenkel Ronald E P, Mani Lakshmi, Toler Allison R, Frenkel Max P C
Eye Research Foundation, Stuart, Florida, USA.
Am J Ophthalmol. 2007 Jun;143(6):1034-5. doi: 10.1016/j.ajo.2007.01.052.
To determine if pegaptanib (Macugen) [Eyetech Pharmaceuticals; Pfizer Inc, New York, New York, USA] injections cause adverse intraocular pressure (IOP) effects in patients with and without glaucoma.
Retrospective chart review.
Review of 75 eyes treated with intravitreal injections of pegaptanib (0.09 ml). The effect of these injections on IOP was analyzed. Most patients received prophylactic IOP-lowering medications.
The mean preinjection IOP based on the first injection of each patient was 14 +/- 3 mm Hg; at one minute postinjection, 38 +/- 14 mm Hg, at three to 10 minutes was 34 +/- 9 mm Hg, and at 11 to 20 minutes was 26 +/-10 mm Hg, respectively. Most patients' IOPs had significantly diminished by 30 minutes postinjection.
Pegaptanib injections result in a significant transient rise in IOP that considerably diminishes by 30 minutes postinjection but can take up to one hour. This may be damaging to the optic nerve, particularly in patients with advanced glaucoma.
确定注射培加他尼（Macugen）[美国纽约辉瑞公司旗下的伊特克制药公司]对患有和未患有青光眼的患者是否会产生不良眼内压（IOP）效应。
回顾性病历审查。
回顾75只接受玻璃体内注射培加他尼（0.09毫升）治疗的眼睛。分析这些注射对眼内压的影响。大多数患者接受了预防性降低眼内压的药物治疗。
基于每位患者首次注射时的平均注射前眼内压为14±3毫米汞柱；注射后1分钟时为38±14毫米汞柱，3至10分钟时为34±9毫米汞柱，11至20分钟时分别为26±10毫米汞柱。大多数患者的眼内压在注射后30分钟时显著下降。
注射培加他尼会导致眼内压显著短暂升高，在注射后30分钟时会大幅下降，但可能需要长达1小时。这对视神经可能有损害，尤其是在晚期青光眼患者中。
