小眼球中的异常黄斑无血管区。
Abnormal foveal avascular zone in nanophthalmos.
作者信息
Walsh Mark K, Goldberg Morton F
机构信息
Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
出版信息
Am J Ophthalmol. 2007 Jun;143(6):1067-1068. doi: 10.1016/j.ajo.2007.01.051.
PURPOSE
To evaluate the foveas of nanophthalmic patients.
DESIGN
Retrospective observational case series.
METHODS
Four nanophthalmic patients examined between April 2005 and April 2006 were included. Visual acuity (VA), refractive correction, axial length, corneal diameter, presence or lack of foveal light reflex, as well as fluorescein angiograms (FAs), and optical coherence tomography (OCT) scans of the maculae were evaluated.
RESULTS
None of the eight eyes had a foveal light reflex, corresponding to lack of a normal foveal pit on OCT. Fluorescein angiography showed no normal foveal avascular zones; all were either completely absent or small and rudimentary.
CONCLUSIONS
Nanophthalmic patients rarely have best-corrected visual acuity (BCVA) better than 20/40 at any point in their lives, even with an absence of known complications, such as uveal effusion or glaucoma. In many patients, this visual deficiency may correspond to an absent or rudimentary foveal avascular zone and lack of a normal foveal pit.
目的
评估小眼球患者的黄斑中心凹。
设计
回顾性观察病例系列。
方法
纳入2005年4月至2006年4月期间检查的4例小眼球患者。评估视力（VA）、屈光矫正、眼轴长度、角膜直径、黄斑中心凹光反射的有无，以及黄斑的荧光素血管造影（FA）和光学相干断层扫描（OCT）。
结果
8只眼中无一例有黄斑中心凹光反射，这与OCT上缺乏正常的黄斑中心凹凹陷相对应。荧光素血管造影显示无正常的黄斑中心凹无血管区；所有区域要么完全缺失，要么小且发育不全。
结论
小眼球患者即使没有已知并发症，如葡萄膜渗漏或青光眼，在其一生中任何时候最佳矫正视力（BCVA）很少能优于20/40。在许多患者中，这种视力缺陷可能与黄斑中心凹无血管区缺失或发育不全以及缺乏正常的黄斑中心凹凹陷有关。
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