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自身免疫性肠病对环孢素A治疗的反应。

Response to autoimmune enteropathy to cyclosporin A therapy.

作者信息

Sanderson I R, Phillips A D, Spencer J, Walker-Smith J A

机构信息

Academic Unit of Paediatric Gastroenterology, Queen Elizabeth Hospital for Children, London.

出版信息

Gut. 1991 Nov;32(11):1421-5. doi: 10.1136/gut.32.11.1421.

DOI:10.1136/gut.32.11.1421
PMID:1752480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1379182/
Abstract

Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is useful in the treatment of autoimmune enteropathy. This report also suggests that T cell activation (which is suppressed by cyclosporin A) is important in the pathogenesis of this condition.

摘要

与自身免疫过程相关的小肠病通常对治疗有抵抗性。两名自身免疫性肠病患儿接受了环孢素A治疗八个月。根据生长情况、小肠黏膜形态和碳水化合物吸收情况评估，两人均有改善。环孢素A对自身免疫性肠病的治疗有用。本报告还表明，T细胞活化（被环孢素A抑制）在这种疾病的发病机制中很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd6/1379182/4ebcdf33310a/gut00592-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd6/1379182/b4fd2d5ecaa5/gut00592-0180-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd6/1379182/4ebcdf33310a/gut00592-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd6/1379182/b4fd2d5ecaa5/gut00592-0180-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bd6/1379182/4ebcdf33310a/gut00592-0181-a.jpg

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