689例连续非亲属活体供肾肾移植中移植肾功能延迟的发生率及危险因素

The incidence and risk factors of delayed graft function in 689 consecutive living unrelated donor renal transplantation.

作者信息

Ghods A J, Savaj S, Abbasi M, Heidari H, Rokhsatyazdi H

机构信息

Division of Nephrology and Transplantation Unit, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Transplant Proc. 2007 May;39(4):846-7. doi: 10.1016/j.transproceed.2007.04.011.

DOI:10.1016/j.transproceed.2007.04.011

PMID:17524828

Abstract

Due to the severe shortage of deceased donor kidneys, the number of renal transplantation from living-related and living-unrelated donors has increased worldwide. The incidence and risk factors of delayed graft function after deceased donor renal transplantation have been extensively studied. In this analysis, the incidence and predictors of delayed graft function was investigated in 689 living-unrelated kidney recipients. In 53 recipients, dialysis was needed within the first week after renal transplantation (7.7%). The risk factors for delayed graft function upon univariate analysis models were: female gender of kidney donor (P=.027), renal allograft with multiple arteries (P=.005) and previous transplantation (P<.005). Upon multivariate analysis, the only risk factor for development of delayed graft function was retransplantation (P=.001).

摘要

由于已故供体肾脏严重短缺，全球范围内来自亲属活体供体和非亲属活体供体的肾移植数量有所增加。已故供体肾移植后移植肾功能延迟的发生率及危险因素已得到广泛研究。在本分析中，对689例非亲属活体肾移植受者的移植肾功能延迟发生率及预测因素进行了调查。53例受者在肾移植后的第一周内需要透析（7.7%）。单因素分析模型中移植肾功能延迟的危险因素为：供体为女性（P=0.027）、移植肾有多支动脉（P=0.005）和既往有移植史（P<0.005）。多因素分析显示，移植肾功能延迟发生的唯一危险因素是再次移植（P=0.001）。