Khosroshahi H T, Oskui R, Shoja M M, Tubbs R S, Ardalan M R
Department of Nephrology, Dialysis and Transplantation, Tabriz Medical University, Tabriz, Iran.
Transplant Proc. 2007 May;39(4):932-3. doi: 10.1016/j.transproceed.2007.04.006.
Diuresis begins soon after renal transplantation. Although controversial, early post kidney transplant urine volume may correlate with favorable short- and long-term allograft survival. The aim of the present study was to examine the potential changes in urine volume within the first 6 months after renal transplantation.
In a prospective study, the first month serum creatinine level and daily urine volume were measured at 24 and 48 hours, and at 1 month after renal transplantation in patients with stable kidney function without the evidence of allograft rejection (n = 54). Fifteen patients were also followed for their urine output at least 6 months post kidney transplantation. Data are expressed in mean values +/- SD. Statistical analysis was performed by SPSS version 13.0 using ANOVA. Correlation between continuous variables was performed using the Pearson test. The P value was set at .05.
The mean age of the renal allograft recipients was 35.5 +/- 12.1 years with a male to female ratio of approximately 1.3. The mean first month serum creatinine was 1.26 +/- 0.4 mg/dL. The mean urine outputs were 10.06 +/- 5.89, 5.45 +/- 3.05, and 3.44 +/- 1.25 L at 24 and 48 hours and 1 month post renal transplantation. Those patients who were followed for 6 months post transplant (n=15) were observed to have a mean urine volume of 3.20 +/- 1.24 L at the end of this period. This trend showed that urine volume steadily decreased from 24 and 48 hours to 1 month after renal transplantation (P<.05). However, urine volumes were rather comparable at one month and 6 months after transplantation (P>.05). A positive correlation was found between the first-month serum creatinine and the urine volume at one month (r=0.302 and P=.035).
Although urine volume showed considerable variation early after renal transplantation, it stabilized by 1 month after transplantation, which was also positively correlated with the first-month serum creatinine. Moreover, we concluded that in stable patients, the final urine output was related to early graft function.
肾移植后很快就会开始利尿。尽管存在争议，但肾移植术后早期尿量可能与短期和长期移植肾存活良好相关。本研究的目的是研究肾移植后前6个月内尿量的潜在变化。
在一项前瞻性研究中，对肾功能稳定且无移植肾排斥证据的患者（n = 54）在肾移植后24小时、48小时及1个月时测量第一个月的血清肌酐水平和每日尿量。15名患者在肾移植后至少随访6个月以观察其尿量。数据以平均值±标准差表示。使用SPSS 13.0软件通过方差分析进行统计分析。连续变量之间的相关性采用Pearson检验。P值设定为0.05。
肾移植受者的平均年龄为35.5±12.1岁，男女比例约为1.3。第一个月的平均血清肌酐为1.26±0.4mg/dL。肾移植后24小时、48小时及1个月时的平均尿量分别为10.06±5.89、5.45±3.05及3.44±1.25L。对移植后随访6个月的患者（n = 15）观察发现，在此期间结束时平均尿量为3.20±1.24L。这一趋势表明，肾移植后尿量从24小时、48小时到1个月稳步下降（P<0.05）。然而，移植后1个月和6个月时的尿量相当（P>0.05）。发现第一个月的血清肌酐与1个月时的尿量呈正相关（r = 0.302，P = 0.035）。
尽管肾移植后早期尿量显示出相当大的变化，但在移植后1个月时趋于稳定，且与第一个月的血清肌酐呈正相关。此外，我们得出结论，在病情稳定的患者中，最终尿量与早期移植肾功能有关。
