Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital Bucheon, Bucheon, Republic of Korea.
Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital Seoul, Seoul, Republic of Korea.
J Int Med Res. 2023 Oct;51(10):3000605231202144. doi: 10.1177/03000605231202144.
To compare the urine output and estimated glomerular filtration rate (eGFR) of patients postoperatively administered sugammadex or glycopyrrolate 7 days following kidney transplantation (KT).
We retrospectively enrolled 134 consecutive patients who underwent KT under general anesthesia. Their urine output and eGFR were recorded every 24 hours between postoperative day (POD) 1 and 7. We used regression analysis to evaluate the relationship between the reversal agent administered and the outcomes of the participants.
The urine output and eGFR of the participants did not differ between the two groups. Multivariate analysis showed that body mass index (BMI) (odds ratio (OR) 1.21; 95% confidence interval (CI) 1.05-1.40), diabetes mellitus (OR 3.14; 95% CI 1.07-9.16), neurovascular disease (OR 7.00; 95% CI 1.61-30.42), and the duration of surgery (OR 1.01; 95% CI 1.00-1.01) were associated with lower urine output on POD 7. In addition, only BMI (OR 1.25; 95% CI 1.09-1.42) was associated with low eGFR on POD 7.
The urine output and eGFR of patients administered sugammadex or glycopyrrolate following KT did not differ 7 days later. Moreover, glycopyrrolate does not affect urine output or eGFR on POD 7, according to multivariate regression analysis.
比较肾移植术后第 7 天接受琥珀酸舒更葡糖钠或格隆溴铵治疗的患者的尿量和估算肾小球滤过率（eGFR）。
我们回顾性纳入了 134 例在全身麻醉下接受肾移植的连续患者。记录术后第 1 天至第 7 天每 24 小时的尿量和 eGFR。我们使用回归分析来评估给予的反转剂与参与者结果之间的关系。
两组患者的尿量和 eGFR 无差异。多变量分析显示体重指数（BMI）（比值比（OR）1.21；95%置信区间（CI）1.05-1.40）、糖尿病（OR 3.14；95% CI 1.07-9.16）、神经血管疾病（OR 7.00；95% CI 1.61-30.42）和手术持续时间（OR 1.01；95% CI 1.00-1.01）与术后第 7 天尿量较低有关。此外，只有 BMI（OR 1.25；95% CI 1.09-1.42）与术后第 7 天的低 eGFR 有关。
接受琥珀酸舒更葡糖钠或格隆溴铵治疗的肾移植患者在第 7 天的尿量和 eGFR 没有差异。此外，根据多变量回归分析，格隆溴铵不会影响术后第 7 天的尿量或 eGFR。
