Salahi H, Nikeghbalian S, Shamsaee A R, Kheradmand E, Sabet B, Jalaeian H, Geramizadeh B, Tanideh N, Malek-Hosseini S A
Shiraz Organ Transplantation Center, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Transplant Proc. 2007 May;39(4):1255-6. doi: 10.1016/j.transproceed.2007.02.059.
The clinical and pathological findings of enteric-drained (ED) versus bladder-drained (BD) pancreas transplantation are still controversial. In this study, we compared early outcome and histological findings of these 2 methods.
In an experimental animal model, after diabetization, 16 dogs were randomly divided into 2 groups. In the first group, the pancreas was transplanted with enteric drainage, and in the second group, with bladder drainage. We evaluated early clinical and pathological outcomes.
The mean survival time was 11.25 +/- 5.0 (range, 5-20) days for group 1 and 13.6 +/- 7.2 (range, 3-23) days for group 2 (P>.05). Fasting blood sugar values (FBS) before transplantation were 279 +/- 26.8 mg/dL versus 278 +/- 41.6 mg/dL, respectively (P>.05). Two weeks postoperative serum FBS had decreased to 84.9 +/- 2.9 versus 84.2 +/- 0.98, respectively (P>.05). Serum amylase in the BD and ED groups were 378.5 +/- 328 versus 422.6 +/- 54.7 mg/dL, respectively (P>.05). Early leakage was not observed in dogs with BD, whereas it was 37.5% among dogs with ED (P<.05). Clinical and pathological evidences of pancreatic necrosis occurred in 37.5% of dogs with BD versus 62.5% of dogs with ED (P>.05).
Although the early outcomes of these drainage methods (ED vs BD) were statistically similar more dogs with ED experienced early complications than with BD.
胰液经肠道引流（ED）与经膀胱引流（BD）的胰腺移植的临床及病理表现仍存在争议。在本研究中，我们比较了这两种方法的早期结局及组织学表现。
在一个实验动物模型中，将16只狗糖尿病化后随机分为两组。第一组进行胰液经肠道引流的胰腺移植，第二组进行胰液经膀胱引流的胰腺移植。我们评估了早期临床及病理结局。
第一组的平均存活时间为11.25±5.0（范围5 - 20）天，第二组为13.6±7.2（范围3 - 23）天（P>0.05）。移植前空腹血糖值（FBS）分别为279±26.8mg/dL和278±41.6mg/dL（P>0.05）。术后两周血清FBS分别降至84.9±2.9和84.2±0.98（P>0.05）。BD组和ED组的血清淀粉酶分别为378.5±328和422.6±54.7mg/dL（P>0.05）。BD组的狗未观察到早期渗漏，而ED组的狗中早期渗漏率为37.5%（P<0.05）。BD组37.5%的狗和ED组62.5%的狗出现胰腺坏死的临床及病理证据（P>0.05）。
尽管这些引流方法（ED与BD）的早期结局在统计学上相似，但与BD组相比，更多接受ED的狗出现了早期并发症。
