Mzayek F, Hassig S, Sherwin R, Hughes J, Chen W, Srinivasan S, Berenson G
Department of Epidemiology, Tulane University Health Sciences Center School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Am J Epidemiol. 2007 Aug 15;166(4):413-20. doi: 10.1093/aje/kwm098. Epub 2007 May 24.
Low birth weight has been found to be associated with cardiovascular mortality and morbidity and with an adverse profile of several cardiovascular risk factors. The inverse association between birth weight and blood pressure was consistently reported from many populations. Using longitudinal data from the Bogalusa Heart Study (Louisiana), the authors investigated the association between birth weight and progression of blood pressure through early adulthood, comparing that relation between African Americans and Whites. Birth data of 2,275 participants, screened two or more times in the Bogalusa Heart Study between 1973 and 2001, were retrospectively obtained from birth certificates and were linked to their clinical, laboratory, and socioeconomic and lifestyle data in the Bogalusa Heart Study data sets. Birth weight was inversely associated with systolic blood pressure, diastolic blood pressure, and pulse pressure (p<or=0.01 for all). For every 1-kg increase in birth weight, systolic blood pressure dropped by 1.9 mmHg (95% confidence interval: -2.6, -1.3), diastolic blood pressure by 0.7 mmHg (95% confidence interval: -1.2, -0.2), and pulse pressure by 1.2 mmHg (95% confidence interval: -1.7, -0.7). The interaction of birth weight with ethnicity was not significant for any outcome. Birth weight was inversely associated with later blood pressure. The strength of that association did not differ between African Americans and Whites.
低出生体重已被发现与心血管疾病死亡率和发病率以及多种心血管危险因素的不良状况相关。许多人群中均一致报道了出生体重与血压之间的负相关关系。作者利用来自博加卢萨心脏研究（路易斯安那州）的纵向数据，调查了出生体重与成年早期血压进展之间的关联，并比较了非裔美国人和白人之间的这种关系。回顾性地从出生证明中获取了1973年至2001年间在博加卢萨心脏研究中接受过两次或更多次筛查的2275名参与者的出生数据，并将其与博加卢萨心脏研究数据集中的临床、实验室、社会经济和生活方式数据相关联。出生体重与收缩压、舒张压和脉压呈负相关（所有p值均≤0.01）。出生体重每增加1千克，收缩压下降1.9毫米汞柱（95%置信区间：-2.6，-1.3），舒张压下降0.7毫米汞柱（95%置信区间：-1.2，-0.2），脉压下降1.2毫米汞柱（95%置信区间：-1.7，-0.7）。出生体重与种族的交互作用对任何结局均无显著影响。出生体重与后期血压呈负相关。非裔美国人和白人之间这种关联的强度没有差异。
