Donker G A, Labarthe D R, Harrist R B, Selwyn B J, Wattigney W, Berenson G S
Epidemiology Research Center, School of Public Health, University of Texas Houston Health Science Center, USA.
Am J Epidemiol. 1997 Mar 1;145(5):387-97. doi: 10.1093/oxfordjournals.aje.a009120.
The hypothesis that birth weight predicts blood pressure inversely at age 7 through 11 years was examined in 1,446 white children and black children in Washington Parish, Louisiana. Two data sets of the Bogalusa Heart Study were merged: 1) newborn cohort participants (n = 233), initially examined at birth, 1973-1974, and reexamined in 1984-1985 at ages 9 through 11 years; and 2) subjects examined at ages 7 through 11 years in 1987-1988 (n = 1,213) whose birth weight was collected from birth certificates in 1991. The prevalence ratios for being in the race-, sex-, and age-specific upper decile of diastolic blood pressure in children born with low birth weight (< 2,500 g) versus those with birth weight > or = 2,500 g were 0.85 (95% confidence interval 0.28-2.56) for white boys, 2.66 (95% confidence interval 1.24-5.70, p < 0.05) for black boys, 1.38 (95% confidence interval 0.63-3.03) for white girls, and 1.05 (95% confidence interval 0.40-2.75) for black girls. For systolic blood pressure, the corresponding prevalence ratio for each race-sex group did not differ from one. When the analyses were restricted to full-term births, prevalence ratios in any race-sex group did not differ from one for systolic and diastolic blood pressure. In multiple linear regression analyses, the concurrently determined Quetelet index (p < 0.001) was a much stronger correlate of systolic and diastolic blood pressure after appropriate adjustment than was birth weight (p > 0.05). From this study, there is some evidence that low birth weight may determine a risk for subsequent high blood pressure in black boys in the age group 7 through 11 years, but the inconsistency of the results for other race-sex groups was unexpected and remains unexplained, if the underlying hypothesis is true.
在路易斯安那州华盛顿教区的1446名白人儿童和黑人儿童中，对出生体重在7至11岁时反向预测血压这一假设进行了检验。将博加卢萨心脏研究的两个数据集合并：1）新生儿队列参与者（n = 233），于1973 - 1974年出生时首次接受检查，并于1984 - 1985年在9至11岁时再次接受检查；2）1987 - 1988年在7至11岁接受检查的受试者（n = 1213），其出生体重于1991年从出生证明中收集。低出生体重（<2500克）的儿童与出生体重≥2500克的儿童相比，白人男孩处于特定种族、性别和年龄组舒张压上十分位数的患病率比值为0.85（95%置信区间0.28 - 2.56），黑人男孩为2.66（95%置信区间1.24 - 5.70，p < 0.05），白人女孩为1.38（95%置信区间0.63 - 3.03），黑人女孩为1.05（95%置信区间0.40 - 2.75）。对于收缩压，每个种族 - 性别组的相应患病率比值与1无差异。当分析仅限于足月出生时，任何种族 - 性别组收缩压和舒张压的患病率比值与1无差异。在多元线性回归分析中，经适当调整后，同时确定的克托莱指数（p < 0.001）与收缩压和舒张压的相关性比出生体重（p > 0.05）更强。从这项研究来看，有一些证据表明低出生体重可能决定7至11岁年龄组黑人男孩后续患高血压的风险，但如果基本假设成立，其他种族 - 性别组结果的不一致出乎意料且仍无法解释。
