角膜缘干细胞移植治疗自身免疫性多腺体综合征相关角膜病变：病例报告及历史文献回顾
Resolution of autoimmune polyglandular syndrome-associated keratopathy with keratolimbal stem cell transplantation: case report and historical literature review.
作者信息
Shah Manan, Holland Edward, Chan Chi-Chao
机构信息
Cincinnati Eye Institute, Edgewood, KY 41017, USA.
出版信息
Cornea. 2007 Jun;26(5):632-5. doi: 10.1097/ICO.0b013e3180415d1a.
Abstract
PURPOSE
To describe the presentation and treatment of a case of autoimmune polyglandular syndrome type 1 (APS1)-associated keratopathy and to review the associated literature.
METHODS
A 23-year-old man with decreased vision secondary to APS1-associated keratopathy was treated with systemic immunosuppression and keratolimbal allograft (KLAL) stem cell transplantation.
RESULTS
The patient maintains excellent vision 27 months after KLAL and systemic immunosuppression.
CONCLUSIONS
An underlying etiology of APS1-associated keratopathy is stem cell deficiency, which can be treated effectively with KLAL and systemic immunosuppression.
摘要
目的
描述1型自身免疫性多腺体综合征（APS1）相关角膜病变的临床表现及治疗方法，并复习相关文献。
方法
一名因APS1相关角膜病变导致视力下降的23岁男性患者接受了全身免疫抑制治疗和角膜缘同种异体移植（KLAL）干细胞移植。
结果
患者在接受KLAL和全身免疫抑制治疗27个月后视力保持良好。
结论
APS1相关角膜病变的潜在病因是干细胞缺乏，可通过KLAL和全身免疫抑制有效治疗。
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