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本文引用的文献

1
Modifier loci condition autoimmunity provoked by Aire deficiency.修饰基因座调节由Aire缺陷引发的自身免疫。
J Exp Med. 2005 Sep 19;202(6):805-15. doi: 10.1084/jem.20050693.
2
The Paton lecture: Ocular surface transplantation: 10 years' experience.
Cornea. 2004 Jul;23(5):425-31. doi: 10.1097/01.ico.0000116529.35249.fa.
3
A comparative study of mRNA and protein expression of the autoimmune regulator gene (Aire) in embryonic and adult murine tissues.胚胎和成年小鼠组织中自身免疫调节基因（Aire）的mRNA和蛋白质表达的比较研究。
J Pathol. 2004 Feb;202(2):180-7. doi: 10.1002/path.1493.
4
The syndrome of keratoconjunctivitis, superficial moniliasis, idiopathic hypoparathyroidism and Addison's disease.角膜结膜炎、浅表念珠菌病、特发性甲状旁腺功能减退症和艾迪生病综合征。
Am J Ophthalmol. 1962 Oct;54:660-74. doi: 10.1016/0002-9394(62)92198-0.
5
Severe secondary ocular changes in a patient suffering from idiopathic hypoparathyroidism and pernicious anaemia.一名患有特发性甲状旁腺功能减退症和恶性贫血的患者出现严重的继发性眼部改变。
Acta Ophthalmol (Copenh). 1959;37:560-7. doi: 10.1111/j.1755-3768.1959.tb03469.x.
6
Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane for treating corneal diseases with total limbal stem cell deficiency.人角膜缘上皮干细胞在羊膜上的体外保存与扩增用于治疗全角膜缘干细胞缺乏的角膜疾病
Adv Exp Med Biol. 2002;506(Pt B):1323-34. doi: 10.1007/978-1-4615-0717-8_192.
7
Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique.角膜缘移植治疗无虹膜角膜病变：一种角膜缘干细胞移植技术。
Ophthalmology. 2003 Jan;110(1):125-30. doi: 10.1016/s0161-6420(02)01451-3.
8
[Chronic keratitis and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome - a case report].
Klin Monbl Augenheilkd. 2001 Dec;218(12):814-7. doi: 10.1055/s-2001-19694.
9
Corneal pathology and outcome of keratoplasty in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Acta Ophthalmol Scand. 2001 Apr;79(2):204-7. doi: 10.1034/j.1600-0420.2001.079002204.x.
10
Chronic bilateral keratitis in autoimmune polyendocrinopathy-candidiadis-ectodermal dystrophy (APECED). A long-term follow-up and visual prognosis.自身免疫性多内分泌腺病-念珠菌病-外胚层营养不良（APECED）中的慢性双侧角膜炎。长期随访及视力预后
Acta Ophthalmol Scand. 2000 Oct;78(5):532-5. doi: 10.1034/j.1600-0420.2000.078005532.x.

角膜缘干细胞移植治疗自身免疫性多腺体综合征相关角膜病变：病例报告及历史文献回顾

Resolution of autoimmune polyglandular syndrome-associated keratopathy with keratolimbal stem cell transplantation: case report and historical literature review.

作者信息

Shah Manan, Holland Edward, Chan Chi-Chao

机构信息

Cincinnati Eye Institute, Edgewood, KY 41017, USA.

出版信息

Cornea. 2007 Jun;26(5):632-5. doi: 10.1097/ICO.0b013e3180415d1a.

DOI:10.1097/ICO.0b013e3180415d1a
PMID:17525667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2111059/
Abstract

PURPOSE

To describe the presentation and treatment of a case of autoimmune polyglandular syndrome type 1 (APS1)-associated keratopathy and to review the associated literature.

METHODS

A 23-year-old man with decreased vision secondary to APS1-associated keratopathy was treated with systemic immunosuppression and keratolimbal allograft (KLAL) stem cell transplantation.

RESULTS

The patient maintains excellent vision 27 months after KLAL and systemic immunosuppression.

CONCLUSIONS

An underlying etiology of APS1-associated keratopathy is stem cell deficiency, which can be treated effectively with KLAL and systemic immunosuppression.

摘要

目的

描述1型自身免疫性多腺体综合征（APS1）相关角膜病变的临床表现及治疗方法，并复习相关文献。

方法

一名因APS1相关角膜病变导致视力下降的23岁男性患者接受了全身免疫抑制治疗和角膜缘同种异体移植（KLAL）干细胞移植。

结果

患者在接受KLAL和全身免疫抑制治疗27个月后视力保持良好。

结论

APS1相关角膜病变的潜在病因是干细胞缺乏，可通过KLAL和全身免疫抑制有效治疗。