McInnes Iain B, Schett Georg
Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.
Nat Rev Immunol. 2007 Jun;7(6):429-42. doi: 10.1038/nri2094.
Cytokines regulate a broad range of inflammatory processes that are implicated in the pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance between pro- and anti-inflammatory cytokine activities favours the induction of autoimmunity, chronic inflammation and thereby joint damage. However, it remains less clear how cytokines are organized within a hierarchical regulatory network, and therefore which cytokines may be the best targets for clinical intervention a priori. Here, we discuss the crucial effector function of cytokines in the immunological processes that are central to the pathogenesis of rheumatoid arthritis.
细胞因子调节广泛的炎症过程，这些过程与类风湿性关节炎的发病机制有关。在类风湿关节中，促炎和抗炎细胞因子活性之间的失衡有利于自身免疫、慢性炎症的诱导，进而导致关节损伤，这是众所周知的。然而，细胞因子如何在分级调节网络中组织起来，以及因此哪些细胞因子可能是先验的临床干预最佳靶点，仍不太清楚。在这里，我们讨论细胞因子在类风湿性关节炎发病机制核心的免疫过程中的关键效应功能。
