Vadlamudi Ratna K, Kumar Rakesh
Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Nucl Recept Signal. 2007 May 17;5:e004. doi: 10.1621/nrs.05004.
Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.
富含脯氨酸、谷氨酸和亮氨酸的蛋白质（PELP）1，也被称为雌激素受体非基因组作用调节剂（MNAR），是一种具有多种功能的新型核受体共调节因子。PELP1/MNAR作为一种支架蛋白，将各种信号复合物与核受体偶联，并参与基因组和非基因组功能。最近的数据表明，PELP1/MNAR在包括乳腺癌、子宫内膜癌、前列腺癌和卵巢癌在内的几种癌症中表达失调，并且PELP1/MNAR与几种癌基因相互作用。在这篇综述中，我们总结了PELP1/MNAR新出现的生物学特性和功能。
