采用直接进样电子轰击电离质谱法分析人尿中的季铵化合物。
The analysis of quaternary ammonium compounds in human urine by direct inlet electron impact ionization mass spectrometry.
作者信息
Nisikawa M, Tatsuno M, Suzuki S, Tsuchihashi H
机构信息
Forensic Science Laboratory, Osaka Prefectural Police Headquarters, Japan.
出版信息
Forensic Sci Int. 1991 Oct;51(1):131-8. doi: 10.1016/0379-0738(91)90213-3.
An accurate and rapid screening test for nine quaternary ammonium compounds (suxamethonium chloride, pancuronium bromide, ambenonium chloride, benzethonium chloride, distigmine bromide, methylbenactyzium bromide, neostigmine bromide, propantheline bromide and pyridostigmine bromide) by direct inlet electron impact ionization mass spectrometry (DI/EI-MS) was investigated. Each compound was extracted from urine as an ion pair with KI3 into dichloromethane. The reliability of the identification of these compounds was verified by the mass chromatographic analysis of their characteristic fragment ions. The analysis of these drugs by DI/EI-MS could be performed within 5 min. The detection limits were between 20-150 ng/ml for the nine compounds. This method appears to be efficient, rapid and suitable as a screening procedure for the quaternary ammonium compounds found in urine.
研究了一种通过直接进样电子轰击电离质谱法（DI/EI-MS）对九种季铵化合物（氯化琥珀胆碱、溴化潘库溴铵、氯化阿伯农、氯化苄乙铵、溴化地斯的明、溴化甲本那辛、溴化新斯的明、溴化丙胺太林和溴化吡啶斯的明）进行准确快速筛选的方法。每种化合物都与KI3形成离子对从尿液中萃取到二氯甲烷中。通过对其特征碎片离子的质量色谱分析验证了这些化合物鉴定的可靠性。通过DI/EI-MS对这些药物的分析可在5分钟内完成。这九种化合物的检测限在20 - 150 ng/ml之间。该方法似乎高效、快速，适合作为尿液中季铵化合物的筛选程序。
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