血浆和尿液中低浓度季铵化合物甲硫酸噻嗪铵的测定。
Determination of low cencentrations of the quaternary ammonium compound thiazinamium methylsulphate in plasma and urine.
作者信息
Jonkman J G, Wijsbeek J, Hollenbeek S, de Boer S H, de Zeeuw R A, Van Bork L E, Orie N G
出版信息
J Pharm Pharmacol. 1975 Nov;27(11):849-54. doi: 10.1111/j.2042-7158.1975.tb10228.x.
A sensitive and selective method for the quantitative determination of the quaternary ammonium antiacetylcholine-compound thiazinamium methylsulphate (Multergan) in plasma and urine is described. The procedure is based on ion pair extraction of the compound with iodide as the counter ion. This is followed by gas chromatography using an alkali flame ionization detector. The detection limit is 2 ng ml-1 with a recovery of 88-0 +/- 6-2% from plasma, 91-4 +/- 4-6% from urine. The described method can also be applied to other quaternary ammonium compounds.
本文描述了一种灵敏且具选择性的方法，用于定量测定血浆和尿液中的季铵类抗乙酰胆碱化合物甲硫酸噻嗪铵（Multergan）。该方法基于以碘化物作为抗衡离子对化合物进行离子对萃取。随后采用碱火焰离子化检测器进行气相色谱分析。检测限为2 ng/ml，血浆回收率为88.0±6.2%，尿液回收率为91.4±4.6%。所描述的方法也可应用于其他季铵化合物。
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