Kia-Keating Brett M, Glatt Stephen J, Tsuang Ming T
Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, California, USA.
Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):1048-53. doi: 10.1002/ajmg.b.30551.
Several studies have suggested that suicidal behavior is at least partially determined by genetic factors, supporting a search for related genes. Two genes that have been highlighted in the literature as being involved are HTR1B, which codes for the serotonin 1B receptor, and COMT, which is related to the inactivation of catecholamines. In order to assess the combined evidence for the numerous studies that have been published relating suicidal behavior to these two genes, two different random effects meta-analyses were conducted utilizing seven studies related to HTR1B and six studies related to COMT. For HTR1B, the combined evidence from 789 case and 1,247 control subjects/participants, suggested that there was no significant association between the HTR1B G861C polymorphism and suicidal behavior. For COMT, based on the combined data from 519 cases and 933 control subjects, there was evidence of a significant association between the COMT 158Met polymorphism and suicidal behavior. Although the results for COMT were not influenced by publication bias, the significance of the combined results was not robust and was related to the gender of the case and control subjects. The results for COMT support past literature that has found a relationship between suicidal behavior and COMT, and has also found that the relationship differs for males and females. Given that in the United States a higher proportion of females attempt suicide, and the higher proportion of males successfully commit suicide, it is possible that COMT is related to the lethality of suicide attempts.
多项研究表明，自杀行为至少部分由遗传因素决定，这支持了对相关基因的探索。文献中突出提到的两个相关基因是HTR1B（编码5-羟色胺1B受体）和COMT（与儿茶酚胺失活有关）。为了评估已发表的众多将自杀行为与这两个基因相关联的研究的综合证据，利用7项与HTR1B相关的研究和6项与COMT相关的研究进行了两项不同的随机效应荟萃分析。对于HTR1B，来自789例病例和1247例对照受试者/参与者的综合证据表明，HTR1B G861C多态性与自杀行为之间无显著关联。对于COMT，基于519例病例和933例对照受试者的综合数据，有证据表明COMT 158Met多态性与自杀行为之间存在显著关联。虽然COMT的结果不受发表偏倚的影响，但综合结果的显著性并不稳健，且与病例和对照受试者的性别有关。COMT的结果支持了过去的文献，即发现自杀行为与COMT之间存在关联，并发现这种关联在男性和女性中有所不同。鉴于在美国女性自杀未遂的比例较高，而男性自杀成功的比例较高，COMT可能与自杀未遂的致死性有关。
