Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, Russia.
Institute of Molecular Genetics of National Research Centre, Kurchatov Institute, 123182 Moscow, Russia.
Genes (Basel). 2021 Jun 4;12(6):861. doi: 10.3390/genes12060861.
It has been previously shown that the serotonin and dopamine neurotransmitter systems might influence the predisposition to suicidal behavior. This study aims to estimate the contribution of 11 polymorphisms in the genes (), , , , (), , , , and to suicidal behavior and severity of symptoms of depression and anxiety in the Russian population. The study was performed on 100 patients with repeated suicide attempts and 154 controls. We first found an association between () 40 bp VNTR locus and suicidal behavior. This association was significant; when using the codominant ( = 0.006), dominant ( = 0.001), overdominant ( = 0.004), and log-additive ( = 0.004) models, LL genotype played a protective role (OR = 0.48, 0.29-0.82, = 0.005). Difference in the distribution of rs4680 genotypes was significant in the codominant ( = 0.04), dominant ( = 0.013), and log-additive ( = 0.02) models, and AA genotype might protect against suicide (OR = 0.49, 0.26-0.91, = 0.025). SLC6A4 5-HTTLPR + rs25531 locus was significant in the recessive model ( = 0.024), and also affected the severity of symptoms of depression ( = 0.044) and personal anxiety ( = 0.029). Our results suggest that allelic variants of , , and genes might be considered as risk factors for suicidal attempts.
先前的研究表明，血清素和多巴胺神经递质系统可能会影响自杀行为的倾向。本研究旨在评估基因中的 11 个多态性（）、（）、（）、（）、（）、（）、（）、（）和（）对俄罗斯人群自杀行为和抑郁、焦虑症状严重程度的影响。该研究共纳入 100 例有反复自杀企图的患者和 154 例对照。我们首先发现（）40bpVNTR 基因座与自杀行为之间存在关联。这种关联具有统计学意义；在使用共显性（=0.006）、显性（=0.001）、超显性（=0.004）和对数相加（=0.004）模型时，LL 基因型发挥保护作用（OR=0.48，0.29-0.82，=0.005）。在共显性（=0.04）、显性（=0.013）和对数相加（=0.02）模型中，rs4680 基因型的分布差异具有统计学意义，AA 基因型可能具有保护作用（OR=0.49，0.26-0.91，=0.025）。SLC6A45-HTTLPR+rs25531 基因座在隐性模型中具有统计学意义（=0.024），并且还影响抑郁症状（=0.044）和个人焦虑（=0.029）的严重程度。我们的研究结果表明，这些基因的等位基因变体可能被视为自杀企图的风险因素。
