大肠杆菌中脱氧核糖核苷酸饥饿状态下双链断裂的产生
Double-strand break generation under deoxyribonucleotide starvation in Escherichia coli.
作者信息
Guarino Estrella, Salguero Israel, Jiménez-Sánchez Alfonso, Guzmán Elena C
机构信息
Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06080-Badajoz, Spain.
出版信息
J Bacteriol. 2007 Aug;189(15):5782-6. doi: 10.1128/JB.00411-07. Epub 2007 May 25.
Abstract
Stalled replication forks produced by three different ways of depleting deoxynucleoside triphosphate showed different capacities to undergo "replication fork reversal." This reaction occurred at the stalled forks generated by hydroxyurea treatment, was impaired under thermal inactivation of ribonucleoside reductase, and did not take place under thymine starvation.
摘要
通过三种不同方式消耗三磷酸脱氧核苷产生的停滞复制叉表现出不同的“复制叉逆转”能力。这种反应发生在羟基脲处理产生的停滞叉处，在核糖核苷酸还原酶热失活时受损，而在胸腺嘧啶饥饿时不发生。
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本文引用的文献
1
Functional taxonomy of bacterial hyperstructures.细菌超结构的功能分类学
Microbiol Mol Biol Rev. 2007 Mar;71(1):230-53. doi: 10.1128/MMBR.00035-06.
2
Role of DNA replication and repair in thymineless death in Escherichia coli.DNA复制与修复在大肠杆菌无胸腺嘧啶死亡中的作用
J Bacteriol. 2006 Jul;188(14):5286-8. doi: 10.1128/JB.00543-06.
3
A fork-clearing role for UvrD.UvrD的叉状清除作用。
Mol Microbiol. 2005 Sep;57(6):1664-75. doi: 10.1111/j.1365-2958.2005.04753.x.
4
Multiple pathways process stalled replication forks.多种途径处理停滞的复制叉。
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12783-8. doi: 10.1073/pnas.0401586101. Epub 2004 Aug 24.
5
RecA-dependent recovery of arrested DNA replication forks.依赖RecA的停滞DNA复制叉的恢复
Annu Rev Genet. 2003;37:611-46. doi: 10.1146/annurev.genet.37.110801.142616.
6
HYDROXYUREA: A SPECIFIC INHIBITOR OF DEOXYRIBONUCLEIC ACID SYNTHESIS.羟基脲：一种脱氧核糖核酸合成的特异性抑制剂。
Biochim Biophys Acta. 1965 Jan 11;95:181-3. doi: 10.1016/0005-2787(65)90225-x.
7
Thymine deficiency and the normal DNA replication cycle. I.胸腺嘧啶缺乏与正常DNA复制周期。I.
J Mol Biol. 1961 Apr;3:144-55. doi: 10.1016/s0022-2836(61)80041-7.
8
The normal DNA replication cycle. II.正常的DNA复制周期。II.
J Mol Biol. 1961 Apr;3:156-65. doi: 10.1016/s0022-2836(61)80042-9.
9
Chromosomal lesion suppression and removal in Escherichia coli via linear DNA degradation.通过线性DNA降解实现大肠杆菌中染色体损伤的抑制与消除
Genetics. 2003 Apr;163(4):1255-71. doi: 10.1093/genetics/163.4.1255.
10
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Mol Microbiol. 2003 May;48(3):845-54. doi: 10.1046/j.1365-2958.2003.03480.x.
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